Phenotypes associated with this allele

• Allele Symbol: Fbxl4^tm1.2Lrsn
• Allele Name: targeted mutation 1.2, Nils-Goran Larsson
• Allele ID: MGI:6514034
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fbxl4^tm1.2Lrsn/Fbxl4^tm1.2Lrsn	involves: C57BL/6N	MGI:6514136

Genotype
MGI:6514136

hm1

• Allelic Composition: Fbxl4^tm1.2Lrsn/Fbxl4^tm1.2Lrsn
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:303084 )

• reduced movement, apathy, and nervousness when handled in 40% of animals starting at age 8-12 months

cellular

decreased mitochondrial DNA content ( J:303084 )

• 25% reduction in E13.5 embryos

• reduced in liver, kidney and brain at age 1 year

• normal in heart and skeletal muscle at age 1 year

decreased mitochondrial number ( J:303084 )

• in liver at age 1 year

abnormal oxidative phosphorylation ( J:303084 )

• reduced complex IV activity in liver mitochondria at age 1 year

growth/size/body

decreased body weight ( J:303084 )

• starting at age 8-12 months

• increased organ weight-to-body weight ratio for most organs starting at age 8-12 months

• normal heart, liver and kidney weight

• normal weight up to age 8-12 months

immune system

liver inflammation ( J:303084 )

• macrophage infiltration at age 1 year

liver/biliary system

liver inflammation ( J:303084 )

• macrophage infiltration at age 1 year

liver degeneration ( J:303084 )

• macrophage infiltration at age 1 year

mortality/aging

preweaning lethality, incomplete penetrance ( J:303084 )

• very few pups recovered (below normal Mendelian ratio) at weaning stage

• normal Mendelian ratio at E13.5 embryonic stage

skeleton

kyphosis ( J:303084 )

• in 60% of animals starting at age 8-12 months

cardiovascular system

cardiovascular system phenotype ( J:303084 )

N • normal heart morphology/histology at age 1 year

renal/urinary system

renal/urinary system phenotype ( J:303084 )

N • normal kidney morphology/histology at age 1 year