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Allele Symbol Allele Name Allele ID |
Cmtm6tm1c(EUCOMM)Wtsi targeted mutation 1c, Wellcome Trust Sanger Institute MGI:6511038 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• increased diameter of sciatic nerve axons 2 and 6 months after treatment with tamoxifen at age 2 months
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• normal internode length and nodal and paranodal dimensions
• normal neurofilament density and phosphorylation
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• increased diameter of phrenic and ventral tail nerve axons
• increased diameter of non-myelinated sciatic nerve axons in Remak bundles at ages P9 and 2 months
• normal myelin sheath thickness to axon diameter ratio for phrenic and ventral tail nerve axons
• normal number of axons per Remak bundle, with no axon diameters larger than 1 micrometer
• normal frequency of developmentally sorted promyelinated axons
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• increased sensory nerve action potential (SNAP)
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• increased sensory nerve conduction velocity (SNCV)
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• increased slipping when walking over a regular grid
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• accelerated reaction in hot plate test
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• absence of spontaneous apnea
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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