Phenotypes associated with this allele

• Allele Symbol: Syisl^em1Bzuo
• Allele Name: endonuclease-mediated mutation 1, Bo Zuo
• Allele ID: MGI:6511001
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Syisl^em1Bzuo/Syisl^em1Bzuo	involves: C57BL/6	MGI:6511002

Genotype
MGI:6511002

hm1

• Allelic Composition: Syisl^em1Bzuo/Syisl^em1Bzuo
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

abnormal myoblast differentiation ( J:266240 )

• marker analysis indicates increased myogenic differentiation of primary myoblasts, with increased number of myotubes but decreased myoblast fusion rate as seen by fewer cell nuclei in each myotube

abnormal myoblast fusion ( J:266240 )

• primary myoblasts show decreased myoblast fusion

decreased myoblast proliferation ( J:266240 )

• leg muscle primary myoblasts exhibit a lower proliferation capacity

increased quadriceps weight ( J:266240 )

• quadriceps muscle weight is increased

increased gastrocnemius weight ( J:266240 )

• gastrocnemius muscle weight is increased

increased tibialis anterior weight ( J:266240 )

• tibialis anterior muscle weight is increased

abnormal skeletal muscle fiber morphology ( J:266240 )

• mice show a lower mean cross-sectional area of individual myofibers

• mice show a higher proportion of smaller myofibers

increased skeletal muscle fiber number ( J:266240 )

• mice show a higher number of myofibers/mm², indicating increased muscle fiber density

• tibialis anterior muscle has a higher total fiber number

enhanced muscle regeneration ( J:266240 )

• at 14 and 18 days following cardiotoxin-induced muscle-injury, mice show faster and increased muscle regeneration compared to controls

• faster muscle-damage repair is mainly attributable to more efficient differentiation of satellite cells

cellular

abnormal myoblast differentiation ( J:266240 )

• marker analysis indicates increased myogenic differentiation of primary myoblasts, with increased number of myotubes but decreased myoblast fusion rate as seen by fewer cell nuclei in each myotube

abnormal myoblast fusion ( J:266240 )

• primary myoblasts show decreased myoblast fusion

decreased myoblast proliferation ( J:266240 )

• leg muscle primary myoblasts exhibit a lower proliferation capacity

growth/size/body

growth/size/body region phenotype ( J:266240 )

N • mice show no differences in weight or growth rate compared to wild-type mice

limbs/digits/tail

increased quadriceps weight ( J:266240 )

• quadriceps muscle weight is increased

increased gastrocnemius weight ( J:266240 )

• gastrocnemius muscle weight is increased

increased tibialis anterior weight ( J:266240 )

• tibialis anterior muscle weight is increased