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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nlrc4em3Vnce
endonuclease-mediated mutation 3, Russell E Vance
MGI:6508703
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nlrc4em3Vnce/Nlrc4em3Vnce C57BL/6-Nlrc4em3Vnce MGI:6509151


Genotype
MGI:6509151
hm1
Allelic
Composition		 Nlrc4em3Vnce/Nlrc4em3Vnce
Genetic
Background		 C57BL/6-Nlrc4em3Vnce
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrc4em3Vnce mutation (1 available); any Nlrc4 mutation (72 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
homeostasis/metabolism phenotype ( J:294930 )
N
• normal level of lactate dehydrogenase (LDH) released by bone marrow derived macrophages exposed to high doses of cytosolic Legionella pneumophila flagellin

immune system
immune system phenotype ( J:294930 )
N
• normal inflammatory response by bone marrow derived macrophages exposed to cytosolic Legionella pneumophila flagellin and mice exposed to L. pneumophila flagellin or orally to S. Typhimurium

mortality/aging
mortality/aging ( J:294930 )
N
• viable

reproductive system




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory