Phenotypes associated with this allele

• Allele Symbol: Tpsg1^tm1.2Rls
• Allele Name: targeted mutation 1.2, Richard L Stevens
• Allele ID: MGI:6508397
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tpsg1^tm1.2Rls/Tpsg1^tm1.2Rls	involves: C57BL/6 * C57BL/6NTac	MGI:6511321

Genotype
MGI:6511321

hm1

• Allelic Composition: Tpsg1^tm1.2Rls/Tpsg1^tm1.2Rls
• Genetic Background: involves: C57BL/6 * C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

decreased susceptibility to colitis induced morbidity/mortality ( J:243813 )

• lower sensitivity to dextran sodium sulfate (DSS)-induced colitis: reduced weight loss, reduced colon shortening, reduced colon histopathology score and lower expression of Il6 and Cxcl2 in colon

respiratory system

respiratory system phenotype ( J:243813 )

N • normal baseline lung function (functional residual, total lung inspiratory and vital capacity, transpulmonary and airway resistance, dynamic compliance and elastance, inertance, and tissue damping)

increased lung elastance ( J:243813 )

• increased dynamic and tissue elastance after methacholine challenge

• normal baseline elastance

abnormal lung hysteresivity ( J:243813 )

• increased after methacholine challenge

increased lung tissue damping ( J:243813 )

• after methacholine challenge

• normal baseline tissue damping

increased airway resistance ( J:243813 )

• increased transpulmonary and airway resistance after methacholine challenge

• normal baseline transpulmonary and airway resistance

decreased lung compliance ( J:243813 )

• decreased dynamic compliance after methacholine challenge

• normal baseline dynamic compliance

growth/size/body

growth/size/body region phenotype ( J:243813 )

N • normal organ histology

immune system

immune system phenotype ( J:243813 )

N • normal mast cell (MC) count and histology in ears and peritoneal cavity

N • normal numbers of circulating monocytes, neutrophils and lymphocytes

decreased susceptibility to colitis induced morbidity/mortality ( J:243813 )

• lower sensitivity to dextran sodium sulfate (DSS)-induced colitis: reduced weight loss, reduced colon shortening, reduced colon histopathology score and lower expression of Il6 and Cxcl2 in colon

mortality/aging

mortality/aging ( J:243813 )

N • viable and normal lifespan

decreased susceptibility to colitis induced morbidity/mortality ( J:243813 )

• lower sensitivity to dextran sodium sulfate (DSS)-induced colitis: reduced weight loss, reduced colon shortening, reduced colon histopathology score and lower expression of Il6 and Cxcl2 in colon

decreased susceptibility to induced morbidity/mortality ( J:243813 )

• lower sensitivity to smoke-induced COPD: no rise in macrophage and neutrophil counts in bronchial alveolar lavage fluid (BALF); attenuated rise of peribronchial, perivascular, and parenchymal inflammatory cells; reduced small airway fibrosis

embryo

embryo phenotype ( J:243813 )

N • no obvious developmental abnormalities