Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(cre/ERT2)Tyj mutation
(3 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Setd4tm1c(KOMP)Wtsi mutation
(0 available);
any
Setd4 mutation
(28 available)
Trp53tm1Brn mutation
(18 available);
any
Trp53 mutation
(232 available)
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mortality/aging
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• after exposure to 4 weekly 2 Gy of total body gamma-irradiation, most tamoxifen-treated adult mice die within 100 days post irradiation
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neoplasm
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• gamma-irradiated tamoxifen-treated mice die mainly of non-disseminated thymic lymphomas, unlike mice that are homozygous for Setd4tm1c(KOMP)Wtsiand heterozygous for Gt(ROSA)26Sortm1(cre/ERT2)Tyj where tumors are widely disseminated to other organs
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• in gamma-irradiated tamoxifen-treated mice, thymic lymphomas are significantly larger in size/weight relative to those in mice that are only homozygous for Setd4tm1c(KOMP)Wtsiand heterozygous for Gt(ROSA)26Sortm1(cre/ERT2)Tyj
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• after exposure to 4 weekly 2 Gy of total body gamma-irradiation, tamoxifen-treated adult mice fail to display a delay in the development of radiation-induced thymic lymphomas
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• sham-irradiated, tamoxifen-treated double mutant mice show accelerated spontaneous tumor development relative to mice that are only homozygous for Trp53tm1Brn and heterozygous for Gt(ROSA)26Sortm1(cre/ERT2)Tyj
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homeostasis/metabolism
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(cre/ERT2)Tyj mutation
(3 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Setd4tm1c(KOMP)Wtsi mutation
(0 available);
any
Setd4 mutation
(28 available)
Trp53tm1Brn mutation
(18 available);
any
Trp53 mutation
(232 available)
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neoplasm
N |
• sham-irradiated, tamoxifen-treated mice show no significant differences in spontaneous tumor development or survival relative to mice that are heterozygous for Trp53tm1Brn and Gt(ROSA)26Sortm1(cre/ERT2)Tyj but wild-type for Setd4
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• after exposure to 4 weekly 2 Gy of total body gamma-irradiation, tamoxifen-treated adult mice fail to display a delay in the development of radiation-induced thymic lymphomas
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(cre/ERT2)Tyj mutation
(3 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Setd4tm1c(KOMP)Wtsi mutation
(0 available);
any
Setd4 mutation
(28 available)
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mortality/aging
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• after exposure to 4 weekly 2 Gy of total body gamma-irradiation, tamoxifen-treated adult mice show delayed thymic lymphoma-mediated death and improved overall survival with a median survival of 245 days versus 195 days in oil-treated controls; 500 days after irradiation, the lymphoma-free survival 22% versus 9.4% in oil-treated controls
• however, non-irradiated tamoxifen-treated adults show no significant differences in survival up to 700 days relative to oil-treated controls
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neoplasm
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• after exposure to total body gamma-irradiation, tamoxifen-treated adult mice exhibit a lower % of cleaved caspase-3 positive cells in their lymphomas than oil-treated controls
• although radiation-induced T cell lymphomas are largely clonogenic, thymic lymphomas of tamoxifen-treated mice are composed mainly of CD4+ CD8+ double positive cells whereas tumors in oil-treated control mice are largely composed of CD8+ single positive cells
• radiation-induced thymic lymphomas of tamoxifen-treated mice exhibit more chromosomal inversions but fewer deletion events than control tumors
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• after exposure to total body gamma-irradiation, tamoxifen-treated adult mice show a more widespread infiltration of peripheral organs (spleen, liver, kidney, and lung) by T-lymphoma cells and a higher tumor dissemination score at the time of death relative to oil-treated controls
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• after exposure to total body gamma-irradiation, tamoxifen-treated adult mice that die within the first 195 days post-irradiation show a slight reduction in the size/weight of lymphomas relative to oil-treated controls
• however, no significant difference in primary thymus tumor weight is noted at the time of death
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• after exposure to total body gamma-irradiation, tamoxifen-treated adult mice show a significant delay in the development of radiation-induced thymic lymphomas and lymphoma-mediated death relative to oil-treated controls, likely due to slower tumor enlargement in the thymus
• however, non-irradiated tamoxifen-treated adults show no obvious growth retardation or tumor development up to 700 days relative to oil-treated controls
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homeostasis/metabolism
cellular
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• after exposure to total body gamma-irradiation, tamoxifen-treated adult mice exhibit a lower percentage of cleaved caspase-3 positive cells in their lymphomas than oil-treated controls
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