Phenotypes associated with this allele

• Allele Symbol: Nup210^{tm1b(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1b, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:6501962
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nup210^tm1b(EUCOMM)Hmgu/Nup210^tm1b(EUCOMM)Hmgu	involves: C57BL/6N	MGI:6268329

Genotype
MGI:6268329

hm1

• Allelic Composition: Nup210^{tm1b(EUCOMM)Hmgu}/Nup210^{tm1b(EUCOMM)Hmgu}
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:266693 )

N • mice exhibit normal thymic sensitivity, antigen-specific T cell response and differentiation of TH2 and TH17 cells

increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:266693 )

• activated CD4+ T cells in the spleen

increased T-helper 1 cell number ( J:266693 )

• increased IFNgamma-producing CD4 and CD8 cells after stimulation

increased CD8-positive, alpha-beta T cell number ( J:266693 )

• activated CD8+ T cells in the spleen

increased central memory CD8 positive, alpha-beta T cell number ( J:266693 )

decreased T cell number ( J:266693 )

• total T cells

• however, gamma-delta T cell numbers are normal

decreased alpha-beta T cell number ( J:266693 )

• T cell-intrinsic

decreased CD4-positive, alpha-beta T cell number ( J:266693 )

• mild decrease in naive CD4+ T cells in the spleen

decreased CD8-positive, alpha-beta T cell number ( J:266693 )

• naive CD8+ T cells in the spleen

• however, T regulatory and T regulatory subset6s are largely intact

hematopoietic system

increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:266693 )

• activated CD4+ T cells in the spleen

increased T-helper 1 cell number ( J:266693 )

• increased IFNgamma-producing CD4 and CD8 cells after stimulation

increased CD8-positive, alpha-beta T cell number ( J:266693 )

• activated CD8+ T cells in the spleen

increased central memory CD8 positive, alpha-beta T cell number ( J:266693 )

decreased T cell number ( J:266693 )

• total T cells

• however, gamma-delta T cell numbers are normal

decreased alpha-beta T cell number ( J:266693 )

• T cell-intrinsic

decreased CD4-positive, alpha-beta T cell number ( J:266693 )

• mild decrease in naive CD4+ T cells in the spleen

decreased CD8-positive, alpha-beta T cell number ( J:266693 )

• naive CD8+ T cells in the spleen

• however, T regulatory and T regulatory subset6s are largely intact