All Phenotypes Dsg2<tm1d(EUCOMM)Wtsi> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dsg2^{tm1d(EUCOMM)Wtsi}/Dsg2^{tm1d(EUCOMM)Wtsi}	involves: C57BL/6J * C57BL/6N	MGI:6501726
ht2	Dsg2^{tm1d(EUCOMM)Wtsi}/Dsg2⁺	involves: C57BL/6J * C57BL/6N	MGI:6501758
cx3	Dsg2^{tm1d(EUCOMM)Wtsi}/Dsg2^{tm1d(EUCOMM)Wtsi} Gsk3b^tm1Dral/Gsk3b^tm1Dral	involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N	MGI:6501734
cx4	Dsg2^{tm1d(EUCOMM)Wtsi}/Dsg2^{tm1d(EUCOMM)Wtsi} Gsk3b^tm1Dral/Gsk3b⁺	involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N	MGI:6501735
cx5	Dsg2^{tm1d(EUCOMM)Wtsi}/Dsg2⁺ Gsk3b^tm1Dral/Gsk3b⁺	involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N	MGI:6501755
cx6	Dsg2^{tm1d(EUCOMM)Wtsi}/Dsg2⁺ Gsk3b^tm1Dral/Gsk3b^tm1Dral	involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N	MGI:6501756

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiac fibrosis ( J:235770 )

• extensive biventricular epicardial and endocardial fibrosis

• exercised mice show extensive biventricular fibrosis

• mice treated daily with the GSK3B inhibitor SB216763 at 3 weeks of age do not exhibit biventricular epicardial and endocardial fibrosis

decreased cardiac muscle contractility ( J:235770 )

• mice show reduced ejection fraction and fractional shortening by 8 weeks of age

• exercised mice show reduced ejection fraction and fractional shortening compared to exercised wild-type mice

• SB216763 treatment improves cardiac function

abnormal heart echocardiography feature ( J:235770 )

• echocardiography shows reduced interventricular septal end-systolic volume, increased left ventricular internal diameter end-diastolic volume and end-systolic volume, decreased left ventricular posterior wall end systole, and reduced fractional shortening and ejection fraction

ventricular premature beat ( J:235770 )

• mice show increased ventricular ectopy

decreased P wave amplitude ( J:235770 )

increased Q wave amplitude ( J:235770 )

prolonged QRS complex duration ( J:235770 )

• prolongation of the average QRS duration

• exercised mice show longer mean QRS complex duration than exercised wild-type mice

• SB216763 treatment normalizes QRS duration

abnormal S wave ( J:235770 )

• mice show reduced S wave amplitude

• exercised mice show reduced S wave amplitude

increased cardiomyocyte apoptosis ( J:235770 )

• exercised mice show numerous TUNEL+ nuclei in the myocardium indicating increased apoptosis compared to exercised wild-type mice

cardiomyopathy ( J:235770 )

• mice develop cardiomyopathy by 8 weeks of age

heart inflammation ( J:235770 )

• biventricular and endocardial inflammation

• exercised mice show extensive biventricular fibrosis and inflammation

• mice treated daily with SB216763 at 3 weeks of age do not exhibit biventricular epicardial and endocardial fibrosis inflammation

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:235770 )

• 55% of mice die while swimming, with mean time of exercise at death of 7.8 +/- 0.6 weeks

• SB216763 treatment improves survival of exercised mice

immune system

heart inflammation ( J:235770 )

• biventricular and endocardial inflammation

• exercised mice show extensive biventricular fibrosis and inflammation

• mice treated daily with SB216763 at 3 weeks of age do not exhibit biventricular epicardial and endocardial fibrosis inflammation

muscle

decreased cardiac muscle contractility ( J:235770 )

• SB216763 treatment improves cardiac function

• mice show reduced ejection fraction and fractional shortening by 8 weeks of age

• exercised mice show reduced ejection fraction and fractional shortening compared to exercised wild-type mice

increased cardiomyocyte apoptosis ( J:235770 )

• exercised mice show numerous TUNEL+ nuclei in the myocardium indicating increased apoptosis compared to exercised wild-type mice

cardiomyopathy ( J:235770 )

• mice develop cardiomyopathy by 8 weeks of age

cellular

increased cardiomyocyte apoptosis ( J:235770 )

• exercised mice show numerous TUNEL+ nuclei in the myocardium indicating increased apoptosis compared to exercised wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
arrhythmogenic right ventricular dysplasia 10		DOID:0110081	OMIM:610193	J:235770

Allelic Composition	Dsg2^{tm1d(EUCOMM)Wtsi}/Dsg2⁺
Genetic Background	involves: C57BL/6J * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dsg2^{tm1d(EUCOMM)Wtsi} mutation (0 available); any Dsg2 mutation (79 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:235770 )

N	• mice show normal cardiac function and histology at rest

abnormal heart electrocardiography waveform feature ( J:235770 )

• mice show abnormal ECG readings in response to exercise

Allelic Composition	Dsg2^{tm1d(EUCOMM)Wtsi}/Dsg2^{tm1d(EUCOMM)Wtsi} Gsk3b^tm1Dral/Gsk3b^tm1Dral
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dsg2^{tm1d(EUCOMM)Wtsi} mutation (0 available); any Dsg2 mutation (79 available)
Gsk3b^tm1Dral mutation (1 available); any Gsk3b mutation (111 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiac fibrosis ( J:235770 )

• hearts show extensive biventricular fibrosis

decreased cardiac muscle contractility ( J:235770 )

• echocardiography shows reduced cardiac function by 8-16 weeks of age, with reduced ejection fraction and fractional shortening

prolonged PR interval ( J:235770 )

increased Q wave amplitude ( J:235770 )

prolonged QRS complex duration ( J:235770 )

abnormal S wave ( J:235770 )

• reduced S-wave amplitude

muscle

decreased cardiac muscle contractility ( J:235770 )

• echocardiography shows reduced cardiac function by 8-16 weeks of age, with reduced ejection fraction and fractional shortening

Allelic Composition	Dsg2^{tm1d(EUCOMM)Wtsi}/Dsg2^{tm1d(EUCOMM)Wtsi} Gsk3b^tm1Dral/Gsk3b⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiac fibrosis ( J:235770 )

• hearts show extensive biventricular fibrosis

decreased cardiac muscle contractility ( J:235770 )

• echocardiography shows reduced cardiac function by 8-16 weeks of age, with reduced ejection fraction and fractional shortening

prolonged PR interval ( J:235770 )

prolonged QRS complex duration ( J:235770 )

abnormal S wave ( J:235770 )

• reduced S-wave amplitude

muscle

decreased cardiac muscle contractility ( J:235770 )

• echocardiography shows reduced cardiac function by 8-16 weeks of age, with reduced ejection fraction and fractional shortening

Allelic Composition	Dsg2^{tm1d(EUCOMM)Wtsi}/Dsg2⁺ Gsk3b^tm1Dral/Gsk3b⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal heart electrocardiography waveform feature ( J:235770 )

• mice exhibit nearly normal cardiac function at 16 weeks of age, although subtle ECG abnormalities are seen

prolonged PR interval ( J:235770 )

prolonged QRS complex duration ( J:235770 )

Allelic Composition	Dsg2^{tm1d(EUCOMM)Wtsi}/Dsg2⁺ Gsk3b^tm1Dral/Gsk3b^tm1Dral
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal heart electrocardiography waveform feature ( J:235770 )

prolonged PR interval ( J:235770 )

prolonged QRS complex duration ( J:235770 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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