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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Dsg2tm1d(EUCOMM)Wtsi
targeted mutation 1d, Wellcome Trust Sanger Institute
MGI:6501716
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Dsg2tm1d(EUCOMM)Wtsi/Dsg2tm1d(EUCOMM)Wtsi involves: C57BL/6J * C57BL/6N MGI:6501726
ht2
Dsg2tm1d(EUCOMM)Wtsi/Dsg2+ involves: C57BL/6J * C57BL/6N MGI:6501758
cx3
Dsg2tm1d(EUCOMM)Wtsi/Dsg2tm1d(EUCOMM)Wtsi
Gsk3btm1Dral/Gsk3btm1Dral
involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N MGI:6501734
cx4
Dsg2tm1d(EUCOMM)Wtsi/Dsg2tm1d(EUCOMM)Wtsi
Gsk3btm1Dral/Gsk3b+
involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N MGI:6501735
cx5
Dsg2tm1d(EUCOMM)Wtsi/Dsg2+
Gsk3btm1Dral/Gsk3b+
involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N MGI:6501755
cx6
Dsg2tm1d(EUCOMM)Wtsi/Dsg2+
Gsk3btm1Dral/Gsk3btm1Dral
involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N MGI:6501756


Genotype
MGI:6501726
hm1
Allelic
Composition
Dsg2tm1d(EUCOMM)Wtsi/Dsg2tm1d(EUCOMM)Wtsi
Genetic
Background
involves: C57BL/6J * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dsg2tm1d(EUCOMM)Wtsi mutation (0 available); any Dsg2 mutation (79 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• extensive biventricular epicardial and endocardial fibrosis
• exercised mice show extensive biventricular fibrosis
• mice treated daily with the GSK3B inhibitor SB216763 at 3 weeks of age do not exhibit biventricular epicardial and endocardial fibrosis
• mice show reduced ejection fraction and fractional shortening by 8 weeks of age
• exercised mice show reduced ejection fraction and fractional shortening compared to exercised wild-type mice
• SB216763 treatment improves cardiac function
• echocardiography shows reduced interventricular septal end-systolic volume, increased left ventricular internal diameter end-diastolic volume and end-systolic volume, decreased left ventricular posterior wall end systole, and reduced fractional shortening and ejection fraction
• mice show increased ventricular ectopy
• prolongation of the average QRS duration
• exercised mice show longer mean QRS complex duration than exercised wild-type mice
• SB216763 treatment normalizes QRS duration
• mice show reduced S wave amplitude
• exercised mice show reduced S wave amplitude
• exercised mice show numerous TUNEL+ nuclei in the myocardium indicating increased apoptosis compared to exercised wild-type mice
• mice develop cardiomyopathy by 8 weeks of age
• biventricular and endocardial inflammation
• exercised mice show extensive biventricular fibrosis and inflammation
• mice treated daily with SB216763 at 3 weeks of age do not exhibit biventricular epicardial and endocardial fibrosis inflammation

mortality/aging
• 55% of mice die while swimming, with mean time of exercise at death of 7.8 +/- 0.6 weeks
• SB216763 treatment improves survival of exercised mice

immune system
• biventricular and endocardial inflammation
• exercised mice show extensive biventricular fibrosis and inflammation
• mice treated daily with SB216763 at 3 weeks of age do not exhibit biventricular epicardial and endocardial fibrosis inflammation

muscle
• mice show reduced ejection fraction and fractional shortening by 8 weeks of age
• exercised mice show reduced ejection fraction and fractional shortening compared to exercised wild-type mice
• SB216763 treatment improves cardiac function
• exercised mice show numerous TUNEL+ nuclei in the myocardium indicating increased apoptosis compared to exercised wild-type mice
• mice develop cardiomyopathy by 8 weeks of age

cellular
• exercised mice show numerous TUNEL+ nuclei in the myocardium indicating increased apoptosis compared to exercised wild-type mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
arrhythmogenic right ventricular dysplasia 10 DOID:0110081 OMIM:610193
J:235770




Genotype
MGI:6501758
ht2
Allelic
Composition
Dsg2tm1d(EUCOMM)Wtsi/Dsg2+
Genetic
Background
involves: C57BL/6J * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dsg2tm1d(EUCOMM)Wtsi mutation (0 available); any Dsg2 mutation (79 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
N
• mice show normal cardiac function and histology at rest
• mice show abnormal ECG readings in response to exercise




Genotype
MGI:6501734
cx3
Allelic
Composition
Dsg2tm1d(EUCOMM)Wtsi/Dsg2tm1d(EUCOMM)Wtsi
Gsk3btm1Dral/Gsk3btm1Dral
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dsg2tm1d(EUCOMM)Wtsi mutation (0 available); any Dsg2 mutation (79 available)
Gsk3btm1Dral mutation (1 available); any Gsk3b mutation (111 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• hearts show extensive biventricular fibrosis
• echocardiography shows reduced cardiac function by 8-16 weeks of age, with reduced ejection fraction and fractional shortening
• reduced S-wave amplitude

muscle
• echocardiography shows reduced cardiac function by 8-16 weeks of age, with reduced ejection fraction and fractional shortening




Genotype
MGI:6501735
cx4
Allelic
Composition
Dsg2tm1d(EUCOMM)Wtsi/Dsg2tm1d(EUCOMM)Wtsi
Gsk3btm1Dral/Gsk3b+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dsg2tm1d(EUCOMM)Wtsi mutation (0 available); any Dsg2 mutation (79 available)
Gsk3btm1Dral mutation (1 available); any Gsk3b mutation (111 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• hearts show extensive biventricular fibrosis
• echocardiography shows reduced cardiac function by 8-16 weeks of age, with reduced ejection fraction and fractional shortening
• reduced S-wave amplitude

muscle
• echocardiography shows reduced cardiac function by 8-16 weeks of age, with reduced ejection fraction and fractional shortening




Genotype
MGI:6501755
cx5
Allelic
Composition
Dsg2tm1d(EUCOMM)Wtsi/Dsg2+
Gsk3btm1Dral/Gsk3b+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dsg2tm1d(EUCOMM)Wtsi mutation (0 available); any Dsg2 mutation (79 available)
Gsk3btm1Dral mutation (1 available); any Gsk3b mutation (111 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• mice exhibit nearly normal cardiac function at 16 weeks of age, although subtle ECG abnormalities are seen




Genotype
MGI:6501756
cx6
Allelic
Composition
Dsg2tm1d(EUCOMM)Wtsi/Dsg2+
Gsk3btm1Dral/Gsk3btm1Dral
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dsg2tm1d(EUCOMM)Wtsi mutation (0 available); any Dsg2 mutation (79 available)
Gsk3btm1Dral mutation (1 available); any Gsk3b mutation (111 available)
phenotype observed in females
phenotype observed in males
N normal phenotype




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory