Phenotypes associated with this allele

• Allele Symbol: Arhgef7^{tm1c(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1c, Wellcome Trust Sanger Institute
• Allele ID: MGI:6501601
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Arhgef7^tm1c(EUCOMM)Wtsi/Arhgef7^tm1c(EUCOMM)Wtsi Tg(Ttr-cre)1Hadj/0	involves: C57BL/6J * C57BL/6N * CBA/J	MGI:6841002
cn2	Arhgef7^tm1c(EUCOMM)Wtsi/Arhgef7^tm1c(EUCOMM)Wtsi Edil3^Tg(Sox2-cre)1Amc/Edil3^+	involves: C57BL/6N * CBA	MGI:6841001

Genotype
MGI:6841002

cn1

• Allelic Composition: Arhgef7^{tm1c(EUCOMM)Wtsi}/Arhgef7^{tm1c(EUCOMM)Wtsi}; Tg(Ttr-cre)1Hadj/0
• Genetic Background: involves: C57BL/6J * C57BL/6N * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

abnormal anterior visceral endoderm cell migration ( J:217373 )

• with reduced directional persistence of migration, small reduction of individual cell migration speed, loss of collectivity, and impaired directing of protrusive activity

abnormal primitive streak morphology ( J:217373 )

• double axis at E7.5

cellular

abnormal anterior visceral endoderm cell migration ( J:217373 )

• with reduced directional persistence of migration, small reduction of individual cell migration speed, loss of collectivity, and impaired directing of protrusive activity

Genotype
MGI:6841001

cn2

• Allelic Composition: Arhgef7^{tm1c(EUCOMM)Wtsi}/Arhgef7^{tm1c(EUCOMM)Wtsi}; Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺
• Genetic Background: involves: C57BL/6N * CBA

embryo

embryo phenotype ( J:217373 )

N • mice exhibit a single primitive streak