Phenotypes associated with this allele

• Allele Symbol: Card11^em2Welu
• Allele Name: endonuclease-mediated mutation 2, Wei Lu
• Allele ID: MGI:6491989
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Card11^em2Welu/Card11^em2Welu	involves: C57BL/6	MGI:6491995
ht2	Card11^em2Welu/Card11^+	involves: C57BL/6	MGI:6491996

Genotype
MGI:6491995

hm1

• Allelic Composition: Card11^em2Welu/Card11^em2Welu
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

enlarged spleen ( J:292926 )

immune system

increased B cell proliferation ( J:292926 )

• germinal center B cells have an accelerated proliferation rate in immunized mice

• germinal center B cells have more cells at S phase compared with wild-type controls, indicating promotion of entry into S phase and proliferation

enlarged spleen ( J:292926 )

increased transitional stage T2 B cell number ( J:292926 )

• a slight decrease in T2 stage B cell percentage during development

abnormal plasma cell differentiation ( J:292926 )

• SRBC-immunized mice show increased plasma cell differentiation in the bone marrow

increased germinal center B cell number ( J:292926 )

• after immunization with the model antigen sheep red blood cells (SRBC), the number of germinal center B cells are increased sightly

decreased mature B cell number ( J:292926 )

• mice exhibit less mature B cells in the bone marrow

increased B-1a cell number ( J:292926 )

• increased in the peritoneal cavity

increased B-1b cell number ( J:292926 )

• increased in the peritoneal cavity

increased marginal zone B cell number ( J:292926 )

• although the percentage of marginal zone B cells in the spleen is similar to wild-type mice, the absolute number of marginal zone B cell numbers is twice as high as that of wild-type

increased pre-B cell number ( J:292926 )

• mice exhibit more pre-B cells in the bone marrow

hematopoietic system

increased B cell proliferation ( J:292926 )

• germinal center B cells have an accelerated proliferation rate in immunized mice

• germinal center B cells have more cells at S phase compared with wild-type controls, indicating promotion of entry into S phase and proliferation

enlarged spleen ( J:292926 )

increased transitional stage T2 B cell number ( J:292926 )

• a slight decrease in T2 stage B cell percentage during development

abnormal plasma cell differentiation ( J:292926 )

• SRBC-immunized mice show increased plasma cell differentiation in the bone marrow

increased germinal center B cell number ( J:292926 )

• after immunization with the model antigen sheep red blood cells (SRBC), the number of germinal center B cells are increased sightly

decreased mature B cell number ( J:292926 )

• mice exhibit less mature B cells in the bone marrow

increased B-1a cell number ( J:292926 )

• increased in the peritoneal cavity

increased B-1b cell number ( J:292926 )

• increased in the peritoneal cavity

increased marginal zone B cell number ( J:292926 )

• although the percentage of marginal zone B cells in the spleen is similar to wild-type mice, the absolute number of marginal zone B cell numbers is twice as high as that of wild-type

increased pre-B cell number ( J:292926 )

• mice exhibit more pre-B cells in the bone marrow

cellular

increased B cell proliferation ( J:292926 )

• germinal center B cells have an accelerated proliferation rate in immunized mice

• germinal center B cells have more cells at S phase compared with wild-type controls, indicating promotion of entry into S phase and proliferation

Genotype
MGI:6491996

ht2

• Allelic Composition: Card11^em2Welu/Card11⁺
• Genetic Background: involves: C57BL/6

immune system

increased B-1 B cell number ( J:292926 )

• B1 B cell development is intermediately enhanced compared with wild-type and homozygous mutants

increased marginal zone B cell number ( J:292926 )

• marginal zone B cell development is intermediately enhanced compared with wild-type and homozygous mutants

hematopoietic system

increased B-1 B cell number ( J:292926 )

• B1 B cell development is intermediately enhanced compared with wild-type and homozygous mutants

increased marginal zone B cell number ( J:292926 )

• marginal zone B cell development is intermediately enhanced compared with wild-type and homozygous mutants