Phenotypes associated with this allele

• Allele Symbol: Marchf2^em1Cnu
• Allele Name: endonuclease-mediated mutation 1, Chungnam National University
• Allele ID: MGI:6490470
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Marchf2^em1Cnu/Marchf2^em1Cnu	C57BL/6-Marchf2^em1Cnu	MGI:6490593

Genotype
MGI:6490593

hm1

• Allelic Composition: Marchf2^em1Cnu/Marchf2^em1Cnu
• Genetic Background: C57BL/6-Marchf2^em1Cnu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:297482 )

• most LPS-treated mice die unlike wild-type mice

immune system

increased circulating interferon-beta level ( J:297482 )

• in vesicular stomatitis virus-infected or poly(I:C)-injected mice

increased circulating interleukin-12 level ( J:297482 )

• in vesicular stomatitis virus- or Listeria monocytogenes-infected or poly(I:C)-injected mice

increased circulating interleukin-6 level ( J:297482 )

• in vesicular stomatitis virus- or Listeria monocytogenes-infected or poly(I:C)-injected mice

increased circulating tumor necrosis factor level ( J:297482 )

• in vesicular stomatitis virus-infected or poly(I:C)-injected mice

increased interleukin-12 secretion ( J:297482 )

• in the spleen and liver of mice infected with Listeria monocytogenes

increased interleukin-6 secretion ( J:297482 )

• in the spleen and liver of mice infected with Listeria monocytogenes

increased susceptibility to endotoxin shock ( J:297482 )

• most LPS-treated mice die unlike wild-type mice

decreased susceptibility to bacterial infection ( J:297482 )

• mice infected with Listeria monocytogenes exhibit reduced bacterial burden with increased IL6, IL12, CCL5, and CXCL10 levels in the serum, spleen and liver compared with wild-type mice

increased susceptibility to bacterial infection induced morbidity/mortality ( J:297482 )

• most LPS-treated mice die unlike wild-type mice

decreased susceptibility to viral infection ( J:297482 )

• mice infected with vesicular stomatitis virus (VSV-GFP) exhibit fewer replicating viruses and elevated cytokines (IFN-beta, IL6, IL12 and TNF-alpha) compared with wild-type mice

homeostasis/metabolism

increased circulating interferon-beta level ( J:297482 )

• in vesicular stomatitis virus-infected or poly(I:C)-injected mice

increased circulating interleukin-12 level ( J:297482 )

• in vesicular stomatitis virus- or Listeria monocytogenes-infected or poly(I:C)-injected mice

increased circulating interleukin-6 level ( J:297482 )

• in vesicular stomatitis virus- or Listeria monocytogenes-infected or poly(I:C)-injected mice

increased circulating tumor necrosis factor level ( J:297482 )

• in vesicular stomatitis virus-infected or poly(I:C)-injected mice