About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Prdm9em2Kpgn
endonuclease-mediated mutation 2, Kenneth Paigen
MGI:6489980
Summary 3 genotypes


Genotype
MGI:6489988
hm1
Allelic
Composition		 Prdm9em2Kpgn/Prdm9em2Kpgn
Genetic
Background		 C57BL/6J-Prdm9em2Kpgn/Kpgn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prdm9em2Kpgn mutation (1 available); any Prdm9 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal DNA methylation during gametogenesis ( J:299008 )
• Background Sensitivity: a 5-fold reduction in the number of Prdm9-dependent H3K4me3 peaks and a decrease in peak intensity is found in homozygous spermatocytes compared with wild-type C57BL/6J, but methyltransferase activity is not abolished as it is in null homozygotes, and only one quarter of the double stranded breaks are at Prdm9-dependent hotspotsverus 85% in C57BL/6J controls while three quarters of the double stranded breaks are found in Prdm9-independent sites versus approximately 4% in C57BL/6J controls

endocrine/exocrine glands

reproductive system
abnormal DNA methylation during gametogenesis ( J:299008 )
• Background Sensitivity: a 5-fold reduction in the number of Prdm9-dependent H3K4me3 peaks and a decrease in peak intensity is found in homozygous spermatocytes compared with wild-type C57BL/6J, but methyltransferase activity is not abolished as it is in null homozygotes, and only one quarter of the double stranded breaks are at Prdm9-dependent hotspotsverus 85% in C57BL/6J controls while three quarters of the double stranded breaks are found in Prdm9-independent sites versus approximately 4% in C57BL/6J controls
reduced female fertility ( J:299008 )
• although homozygous females are sub-fertile, they do reproduce




Genotype
MGI:6500995
hm2
Allelic
Composition		 Prdm9em2Kpgn/Prdm9em2Kpgn
Genetic
Background		 (C57BL/6J-Prdm9em2Kpgn/Kpgn x WSB/EiJ)F2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prdm9em2Kpgn mutation (1 available); any Prdm9 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands

reproductive system




Genotype
MGI:6490002
ht3
Allelic
Composition		 Prdm9em2Kpgn/Prdm9+
Genetic
Background		 C57BL/6J-Prdm9em2Kpgn/Kpgn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prdm9em2Kpgn mutation (1 available); any Prdm9 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
decreased oocyte number ( J:299008 )
• heterozygotes have an intermediate phenotype with fewer than normal oocytes but more than those found in homozygotes

reproductive system
decreased oocyte number ( J:299008 )
• heterozygotes have an intermediate phenotype with fewer than normal oocytes but more than those found in homozygotes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory