Phenotypes associated with this allele

• Allele Symbol: Sh3yl1^tm1Syb
• Allele Name: targeted mutation 1, Yun Soo Bae
• Allele ID: MGI:6489952
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sh3yl1^tm1Syb/Sh3yl1^tm1Syb	involves: C57BL/6N	MGI:6490301

Genotype
MGI:6490301

hm1

• Allelic Composition: Sh3yl1^tm1Syb/Sh3yl1^tm1Syb
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

cellular phenotype ( J:298830 )

N • normal reactive oxygen species (ROS) generation increase upon stimulation of smooth muscle cells (SMCs) with TLR2 agonist Pam3CSK4 or PMA stimulation of bone marrow-derived monocytes

decreased kidney apoptosis ( J:298830 )

• reduced apoptosis after LPS injection

decreased renal tubule apoptosis ( J:298830 )

• reduced apoptosis upon LPS stimulation of renal tubular epithelial cells (RTECs)

homeostasis/metabolism

abnormal response/metabolism to endogenous compounds ( J:298830 )

• no increase in intra- or extracellular hydrogen peroxide generation upon LPS stimulation of renal tubular epithelial cells (RTECs)

• suppressed extracellular hydrogen peroxide generation by kidneys after LPS injection

• attenuated TNFA and IL1b induction upon LPS stimulation of renal tubular epithelial cells (RTECs)

• no TNFA and IL1b production by kidneys after LPS injection

immune system

decreased interleukin-1 beta secretion ( J:298830 )

• attenuated IL1b induction upon LPS stimulation of renal tubular epithelial cells (RTECs)

decreased tumor necrosis factor secretion ( J:298830 )

• attenuated TNFA induction upon LPS stimulation of renal tubular epithelial cells (RTECs)

decreased susceptibility to endotoxin shock ( J:298830 )

• significantly increased survival rate after LPS injection

• no increase in intra- or extracellular hydrogen peroxide generation upon LPS stimulation of renal tubular epithelial cells (RTECs)

• suppressed extracellular hydrogen peroxide generation by kidneys after LPS injection

• attenuated TNFA and IL1b induction upon LPS stimulation of renal tubular epithelial cells (RTECs)

• no TNFA and IL1b production by kidneys after LPS injection

• no acute kidney injury (AKI) after LPS injection

• suppressed macrophage and neutrophil infiltration of kidney after LPS induction

• reduced kidney apoptosis after LPS injection

• no glomerular swelling after LPS injection

mortality/aging

decreased susceptibility to induced morbidity/mortality ( J:298830 )

• significantly increased survival rate after LPS injection

• no acute kidney injury (AKI) after LPS injection

• suppressed macrophage and neutrophil infiltration of kidney after LPS induction

• reduced kidney apoptosis after LPS injection

• no glomerular swelling after LPS injection

renal/urinary system

decreased kidney apoptosis ( J:298830 )

• reduced apoptosis after LPS injection

decreased renal tubule apoptosis ( J:298830 )

• reduced apoptosis upon LPS stimulation of renal tubular epithelial cells (RTECs)