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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gas5em1Gpt
endonuclease-mediated mutation 1, GemPharmatech Co., Ltd
MGI:6489537
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gas5em1Gpt/Gas5em1Gpt C57BL/6JGpt-Gas5em1Gpt/Gpt MGI:6489555
ht2
 		Gas5em1Gpt/Gas5+ C57BL/6JGpt-Gas5em1Gpt/Gpt MGI:6489556


Genotype
MGI:6489555
hm1
Allelic
Composition		 Gas5em1Gpt/Gas5em1Gpt
Genetic
Background		 C57BL/6JGpt-Gas5em1Gpt/Gpt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gas5em1Gpt mutation (0 available); any Gas5 mutation (63 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality ( J:298688 )
• all mice die during the embryonic period




Genotype
MGI:6489556
ht2
Allelic
Composition		 Gas5em1Gpt/Gas5+
Genetic
Background		 C57BL/6JGpt-Gas5em1Gpt/Gpt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gas5em1Gpt mutation (0 available); any Gas5 mutation (63 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
impaired osteoblast differentiation ( J:298688 )
• bone marrow stromal cells exhibit decreased osteoblast differentiation ability
abnormal bone healing ( J:298688 )
• mice exhibit impaired bone repair capacity on cranial bone
decreased bone volume ( J:298688 )
• bone volume to total volume is decreased
abnormal trabecular bone morphology ( J:298688 )
• mice exhibit less femoral cancellous bone
osteoporosis ( J:298688 )
• mice exhibit an osteoporotic phenotype

homeostasis/metabolism
abnormal bone healing ( J:298688 )
• mice exhibit impaired bone repair capacity on cranial bone

cellular
impaired osteoblast differentiation ( J:298688 )
• bone marrow stromal cells exhibit decreased osteoblast differentiation ability




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory