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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fan1em2Mem
endonuclease-mediated mutation 2, Marcy E MacDonald
MGI:6489296
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Fan1em2Mem/Fan1em2Mem C57BL/6J-Fan1em2Mem MGI:6489861
cx2
 		Fan1em2Mem/Fan1em2Mem
Htttm3Mem/Htt+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:6489858
cx3
 		Fan1em2Mem/Fan1+
Htttm3Mem/Htt+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:6489859
cx4
 		Fan1em2Mem/Fan1em2Mem
Htttm5Mem/Htt+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:6489862


Genotype
MGI:6489861
hm1
Allelic
Composition		 Fan1em2Mem/Fan1em2Mem
Genetic
Background		 C57BL/6J-Fan1em2Mem
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fan1em2Mem mutation (0 available); any Fan1 mutation (98 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell nucleus size ( J:298297 )
• karyomegaly in the kidney at 5 months
increased cellular sensitivity to alkylating agents ( J:298297 )
• in response to mitomycin C in embryonic fibroblasts




Genotype
MGI:6489858
cx2
Allelic
Composition		 Fan1em2Mem/Fan1em2Mem
Htttm3Mem/Htt+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fan1em2Mem mutation (0 available); any Fan1 mutation (98 available)
Htttm3Mem mutation (1 available); any Htt mutation (176 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell physiology ( J:298297 )
• some expansion of the Htt CAG triplet repeats in striatum and liver at 8 months of age




Genotype
MGI:6489859
cx3
Allelic
Composition		 Fan1em2Mem/Fan1+
Htttm3Mem/Htt+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fan1em2Mem mutation (0 available); any Fan1 mutation (98 available)
Htttm3Mem mutation (1 available); any Htt mutation (176 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell physiology ( J:298297 )
• expansion of the Htt CAG triplet repeats in striatum and liver at 8 months of age




Genotype
MGI:6489862
cx4
Allelic
Composition		 Fan1em2Mem/Fan1em2Mem
Htttm5Mem/Htt+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fan1em2Mem mutation (0 available); any Fan1 mutation (98 available)
Htttm5Mem mutation (2 available); any Htt mutation (176 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell physiology ( J:298297 )
• expansion of the Htt CAG triplet repeats in striatum and liver at 5 months of age




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory