All Phenotypes Ubr5<em1Mem> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ubr5^em1Mem
endonuclease-mediated mutation 1, Marcy E MacDonald
MGI:6489293

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ubr5^em1Mem/Ubr5^em1Mem	C57BL/6J-Ubr5^em1Mem	MGI:6489873
cx2	Htt^tm5Mem/Htt⁺ Ubr5^em1Mem/Ubr5⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:6489874

Allelic Composition	Ubr5^em1Mem/Ubr5^em1Mem
Genetic Background	C57BL/6J-Ubr5^em1Mem

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ubr5^em1Mem mutation (0 available); any Ubr5 mutation (117 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:298297 )

• fewer than expected mice are present at weaning

Allelic Composition	Htt^tm5Mem/Htt⁺ Ubr5^em1Mem/Ubr5⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htt^tm5Mem mutation (2 available); any Htt mutation (179 available)
Ubr5^em1Mem mutation (0 available); any Ubr5 mutation (117 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal cell physiology ( J:298297 )

• expansion of the Htt CAG triplet repeats in striatum and liver at 5 months of age

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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