Phenotypes associated with this allele

• Allele Symbol: Fbxw5^em1Syli
• Allele Name: endonuclease-mediated mutation 1, Shuyan Li
• Allele ID: MGI:6488664
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fbxw5^em1Syli/Fbxw5^em1Syli	C57BL/6-Fbxw5^em1Syli	MGI:6489263

Genotype
MGI:6489263

hm1

• Allelic Composition: Fbxw5^em1Syli/Fbxw5^em1Syli
• Genetic Background: C57BL/6-Fbxw5^em1Syli

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:298305 )

N • mice exhibit normal basal cardiac function

increased heart weight ( J:298305 )

• following transaortic constriction

• however, infection with an Fbxw5-expressing adenovirus rescues protects mice from cardiac hypertrophy and treatment with iTAK1 5Z-7-oxozeaenol to inhibit TAK1 phosphorylation abolishes the sensitivity to cardiac hypertrophy

cardiac hypertrophy ( J:298305 )

• following transaortic constriction

• however, infection with an Fbxw5-expressing adenovirus rescues protects mice from cardiac hypertrophy and treatment with iTAK1 5Z-7-oxozeaenol to inhibit TAK1 phosphorylation abolishes the sensitivity to cardiac hypertrophy

dilated heart left ventricle ( J:298305 )

• increased left ventricle end diastolic/systolic diameter following transaortic constriction

• however, infection with an Fbxw5-expressing adenovirus rescues protects mice from cardiac hypertrophy and treatment with iTAK1 5Z-7-oxozeaenol to inhibit TAK1 phosphorylation abolishes the sensitivity to cardiac hypertrophy

cardiac fibrosis ( J:298305 )

• increased collagen content in both the perivascular and interstitial spaces following transaortic constriction

cardiac interstitial fibrosis ( J:298305 )

• following transaortic constriction

• however, treatment with iTAK1 5Z-7-oxozeaenol to inhibit TAK1 phosphorylation abolishes the sensitivity to cardiac hypertrophy

decreased cardiac muscle contractility ( J:298305 )

• lower fractional shortening and ejection fraction following transaortic constriction

• however, infection with an Fbxw5-expressing adenovirus rescues protects mice from cardiac hypertrophy and treatment with iTAK1 5Z-7-oxozeaenol to inhibit TAK1 phosphorylation abolishes the sensitivity to cardiac hypertrophy

increased susceptibility to myocardial ischemic injury ( J:298305 )

• following transaortic constriction, mice exhibit increased heart and lung weight, decreased heart function (increased left ventricle end diastolic/systolic diameter, and lower fractional shortening and ejection fraction), and increased collagen content compared with control mice

• however, infection with an Fbxw5-expressing adenovirus rescues protects mice from cardiac hypertrophy and treatment with iTAK1 5Z-7-oxozeaenol to inhibit TAK1 phosphorylation abolishes the sensitivity to cardiac hypertrophy

growth/size/body

increased heart weight ( J:298305 )

• following transaortic constriction

• however, infection with an Fbxw5-expressing adenovirus rescues protects mice from cardiac hypertrophy and treatment with iTAK1 5Z-7-oxozeaenol to inhibit TAK1 phosphorylation abolishes the sensitivity to cardiac hypertrophy

cardiac hypertrophy ( J:298305 )

• following transaortic constriction

• however, infection with an Fbxw5-expressing adenovirus rescues protects mice from cardiac hypertrophy and treatment with iTAK1 5Z-7-oxozeaenol to inhibit TAK1 phosphorylation abolishes the sensitivity to cardiac hypertrophy

increased lung weight ( J:298305 )

• following transaortic constriction

• however, infection with an Fbxw5-expressing adenovirus rescues protects mice from cardiac hypertrophy and treatment with iTAK1 5Z-7-oxozeaenol to inhibit TAK1 phosphorylation abolishes the sensitivity to cardiac hypertrophy

homeostasis/metabolism

increased susceptibility to myocardial ischemic injury ( J:298305 )

• following transaortic constriction, mice exhibit increased heart and lung weight, decreased heart function (increased left ventricle end diastolic/systolic diameter, and lower fractional shortening and ejection fraction), and increased collagen content compared with control mice

• however, infection with an Fbxw5-expressing adenovirus rescues protects mice from cardiac hypertrophy and treatment with iTAK1 5Z-7-oxozeaenol to inhibit TAK1 phosphorylation abolishes the sensitivity to cardiac hypertrophy

muscle

decreased cardiac muscle contractility ( J:298305 )

• lower fractional shortening and ejection fraction following transaortic constriction

• however, infection with an Fbxw5-expressing adenovirus rescues protects mice from cardiac hypertrophy and treatment with iTAK1 5Z-7-oxozeaenol to inhibit TAK1 phosphorylation abolishes the sensitivity to cardiac hypertrophy

respiratory system

increased lung weight ( J:298305 )

• following transaortic constriction

• however, infection with an Fbxw5-expressing adenovirus rescues protects mice from cardiac hypertrophy and treatment with iTAK1 5Z-7-oxozeaenol to inhibit TAK1 phosphorylation abolishes the sensitivity to cardiac hypertrophy

cellular

cardiac interstitial fibrosis ( J:298305 )

• following transaortic constriction

• however, treatment with iTAK1 5Z-7-oxozeaenol to inhibit TAK1 phosphorylation abolishes the sensitivity to cardiac hypertrophy