Phenotypes associated with this allele

• Allele Symbol: Trim7^em1Jiew
• Allele Name: endonuclease-mediated mutation 1, Jie Wang
• Allele ID: MGI:6478305
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trim7^em1Jiew/Trim7^em1Jiew	C57BL/6-Trim7^em1Jiew	MGI:6478318

Genotype
MGI:6478318

hm1

• Allelic Composition: Trim7^em1Jiew/Trim7^em1Jiew
• Genetic Background: C57BL/6-Trim7^em1Jiew

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased susceptibility to viral infection ( J:292408 )

• higher expression levels of IFNB, IP-10 and TNFA upon stimulation of cultured bone marrow-derived dendritic cells (BMDCs), bone marrow-derived macrophages (BMMs) or mouse embryonic fibroblasts (MEFs) with cytosolic DNA (HSV60, VACV70, HT DNA, ISD, cGAMP or poly(dA:dT))

decreased susceptibility to Herpesvirales infection ( J:292408 )

• increased MITA expression and the phosphorylation of TBK1, IRF3, p65 and IkBa in cultured bone marrow-derived dendritic cells (BMDCs) after infection with HSV-1 or HSV60

• lower level of K48-linked ubiquitination of MITA in cultured bone marrow-derived dendritic cells (BMDCs) after infection with HSV-1

• decreased virus titer in cultured bone marrow-derived macrophages (BMMs) after infection with HSV-1

• higher expression levels of IFNB, IP-10 and TNFA in liver and lungs and higher serum IFN and TNFA levels after intraperitoneal/intravenous injection with HSV-1

• decreased HSV-1 DNA levels in liver and lungs after intraperitoneal/intravenous injection with HSV-1

• decreased virus titer in peritoneal wash fluid after intraperitoneal/intravenous injection with HSV-1

• reduced lung damage after intraperitoneal/intravenous injection with HSV-1

• increased survival rates after intraperitoneal/intravenous injection with HSV-1