Phenotypes associated with this allele

• Allele Symbol: Fam3a^em1Cya
• Allele Name: endonuclease-mediated mutation 1, Cyagen Biosciences
• Allele ID: MGI:6477316
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fam3a^em1Cya/Fam3a^em1Cya	involves: C57BL/6	MGI:6477388

Genotype
MGI:6477388

hm1

• Allelic Composition: Fam3a^em1Cya/Fam3a^em1Cya
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased T cell number ( J:295206 )

♀ • increased CD3+ cell number in liver when subjected to 70% liver ischemia reperfusion injury (IRI)

increased NK T cell number ( J:295206 )

♀ • increased CD16+ cell number in liver when subjected to 70% liver ischemia reperfusion injury (IRI)

increased macrophage cell number ( J:295206 )

♀ • increased F4/80+ cell number in liver when subjected to 70% liver ischemia reperfusion injury (IRI)

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:293249 )

♀N • no change in glucose tolerance, insulin resistance, hyperglycemia, body weight increase, fasting blood glucose levels, steatosis and serum lipid levels compared to wild-type when fed high-fat diet (HFD), with or without doxepin treatment

increased circulating alanine transaminase level ( J:295206 )

♀ • when subjected to 70% liver ischemia reperfusion injury (IRI)

increased circulating aspartate transaminase level ( J:295206 )

♀ • when subjected to 70% liver ischemia reperfusion injury (IRI)

increased circulating glutamate dehydrogenase level ( J:295206 )

♀ • increased GDH activity when subjected to 70% liver ischemia reperfusion injury (IRI)

decreased superoxide dismutase level ( J:295206 )

♀ • when subjected to 70% liver ischemia reperfusion injury (IRI)

abnormal nitric oxide homeostasis ( J:295206 )

♀ • increased NO level in liver when subjected to 70% liver ischemia reperfusion injury (IRI)

hematopoietic system

increased T cell number ( J:295206 )

♀ • increased CD3+ cell number in liver when subjected to 70% liver ischemia reperfusion injury (IRI)

increased NK T cell number ( J:295206 )

♀ • increased CD16+ cell number in liver when subjected to 70% liver ischemia reperfusion injury (IRI)

increased macrophage cell number ( J:295206 )

♀ • increased F4/80+ cell number in liver when subjected to 70% liver ischemia reperfusion injury (IRI)

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:295206 )

♀ • increased liver damage when subjected to 70% liver ischemia reperfusion injury (IRI)

♀ • reduced total anti-oxidative capacity (T-AOC) when subjected to liver IRI

♀ • increased methane dicarboxylic aldehyde (MDA) levels and myeloperoxidase (MPO) activity when subjected to liver IRI

♀ • reduced cellular ATP levels in liver when subjected to liver IRI