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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Sinhcaftm1.2Hmd
targeted mutation 1.2, Hiroshi Hamada
MGI:6474233
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Sinhcaftm1.2Hmd/Sinhcaftm1.2Hmd involves: 129 * C57BL/6 MGI:7310288


Genotype
MGI:7310288
hm1
Allelic
Composition
Sinhcaftm1.2Hmd/Sinhcaftm1.2Hmd
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sinhcaftm1.2Hmd mutation (0 available); any Sinhcaf mutation (53 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mutants are detected at the expected frequency at E9.5 and E10.5, but numbers decline thereafter and are greatly decreased at E18.5 and mice are born at a frequency much lower than expected

cardiovascular system
• embryos exhibit shortening of the outflow tract already at E9.5
• cell proliferation is reduced in the septum transversum, secondary heart field, and proepicardium at E9-E9.5 but is unaffected in the heart ventricle
• many mutants that survive to E18.5 exhibit double-outlet right ventricle
• many mutants that survive to E18.5 exhibit transposition of the great arteries
• many mutants that survive to E18.5 exhibit ventricular septum defects
• smaller at E13.5

digestive/alimentary system
• many mutants that survive to E18.5 exhibit abnormal rotation of the gut
• gut is smaller at E13.5

embryo
• embryos show growth retardation at E9.5
• embryos show neural tube defects at E9.5
• cell proliferation is slightly increased in the neural tube at E9-E9.5
• cell proliferation is reduced in the septum transversum at E9-E9.5

growth/size/body
• embryos show growth retardation at E9.5

hematopoietic system
• many mutants that survive to E18.5 exhibit spleen hypoplasia

immune system
• many mutants that survive to E18.5 exhibit spleen hypoplasia

liver/biliary system
• smaller at E13.5

nervous system
• embryos show neural tube defects at E9.5
• cell proliferation is slightly increased in the neural tube at E9-E9.5

respiratory system
• many mutants that survive to E18.5 exhibit incomplete lobulation of the lungs





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory