Analysis Tools
mortality/aging
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• mice exhibit reduced viability over time
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growth/size/body
homeostasis/metabolism
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• increase in blood urea nitrogen level
• however, no differences in blood or urine creatinine levels are seen
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• mice fed a high-fat Western diet show an approximate 2-fold and 1.5-fold increase in LDL-cholesterol in females and males, respectively
• however, mice fed a high-fat Western diet show no differences from wild-type in the total cholesterol or triglyceride levels
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• mice exhibit low-molecular-weight proteinuria, with mice showing increased levels of the low molecular weight proteins vitamin D binding protein, alpha1-microglobulin, and retinol binding protein in the urine
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albuminuria
(
J:287843
)
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• increase in albumin-to-creatinine ratio, suggesting a defect in kidney absorption of albumin
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renal/urinary system
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• mice exhibit low-molecular-weight proteinuria, with mice showing increased levels of the low molecular weight proteins vitamin D binding protein, alpha1-microglobulin, and retinol binding protein in the urine
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albuminuria
(
J:287843
)
|
• increase in albumin-to-creatinine ratio, suggesting a defect in kidney absorption of albumin
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• PNA-reactive O-glycans are not seen along the apical surface of kidney proximal tubules
• mice show an age-related decline in megalin abundance along the surface of the proximal tubules
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