Analysis Tools
growth/size/body
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• slight but significant decrease in weight in males
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• no difference in body weight on standard or high fat diets in either male or female mice
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vision/eye
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• melanophagy in the iris or the ciliary body
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• retinal atrophy
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• responses in vision and touch escape assays suggest ophthalmologic defects lead to blindness
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homeostasis/metabolism
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• no difference in body weight on standard or high fat diets in either male or female mice
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• on a high fat diet glucose levels do not increase unlike in diet matched wild-type controls
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• on a high fat diet insulin levels do not increase unlike in diet matched wild-type controls
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• on a high fat diet glucose tolerance is not impaired unlike in diet matched wild-type controls
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• following insulin injection mice show a greater decrease in blood glucose at 30, 45, and 90 minutes post injection
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digestive/alimentary system
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• on a high fat diet
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• increase in fat content, including concentrations of free fatty acids, cholesterol and triglycerides, when on a high fat or standard diet
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adipose tissue
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• in males
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behavior/neurological
| N |
• no difference in food intake is seen compared to wild type mice on either standard or high-fat diets
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