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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Crb1em3Jnk
endonuclease-mediated mutation 3, Jeremy N Kay
MGI:6467933
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Crb1em3Jnk/Crb1em3Jnk involves: C57BL/6J * SJL MGI:6467935


Genotype
MGI:6467935
hm1
Allelic
Composition		 Crb1em3Jnk/Crb1em3Jnk
Genetic
Background		 involves: C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crb1em3Jnk mutation (0 available); any Crb1 mutation (92 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal photoreceptor inner segment morphology ( J:293375 )
• within disrupted regions, photoreceptor inner segments lack electron-dense junctions due to disruption of photoreceptor-Muller contacts
abnormal retina outer limiting membrane morphology ( J:293375 )
• mice exhibit disruptions at the outer limiting membrane; photoreceptor nuclei invade the inner segment layer, disturbing the structure of the outer retina

nervous system
abnormal photoreceptor inner segment morphology ( J:293375 )
• within disrupted regions, photoreceptor inner segments lack electron-dense junctions due to disruption of photoreceptor-Muller contacts




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory