Phenotypes associated with this allele

• Allele Symbol: Camsap1^tm1Wem
• Allele Name: targeted mutation 1, Wenxiang Meng
• Allele ID: MGI:6467782
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Camsap1^tm1Wem/Camsap1^tm1Wem	involves: C57BL/6J	MGI:6467826

Genotype
MGI:6467826

hm1

• Allelic Composition: Camsap1^tm1Wem/Camsap1^tm1Wem
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

seizures ( J:296029 )

• mice die from epileptic seizures

nervous system

seizures ( J:296029 )

• mice die from epileptic seizures

abnormal neuronal migration ( J:296029 )

• increased accumulation of neurons in intermediate zone (IZ) instead of cortical plate (CP) in embryonic neocortex at stage E18.5

abnormal telencephalon development ( J:296029 )

• disturbed organization of cortical layers (II-IV, VI) in neonatal and 21-day old mice

decreased brain size ( J:296029 )

abnormal neuron polarity ( J:296029 )

• most neurons accumulate in multipolar migration zone (MMZ) of embryonic neocortex at stage E17.5

• fewer unbranched uni- or bipolar neurons in embryonic neocortex at stage E17.5

• more multipolar and branched uni- or bipolar neurons in embryonic neocortex at stage E17.5

• reduced microtubule distribution differential in neurites of stage 3 neurons

• no microtubule distribution changes (i.e. accumulation in axons) in stage 3 neurons

mortality/aging

lethality during fetal growth through weaning, incomplete penetrance ( J:296029 )

• majority dies from epileptic seizures by age P18-21

perinatal lethality, incomplete penetrance ( J:296029 )

• 50% higher mortality rate in first 2 days after birth

cellular

abnormal microtubule cytoskeleton morphology ( J:296029 )

• reduced microtubule distribution differential in neurites of stage 3 neurons

• no microtubule distribution changes (i.e. accumulation in axons) in stage 3 neurons

abnormal neuronal migration ( J:296029 )

• increased accumulation of neurons in intermediate zone (IZ) instead of cortical plate (CP) in embryonic neocortex at stage E18.5