Analysis Tools
mortality/aging
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• mice show retarded follicle development from pre-antral follicles to antral follicles, while the chromatin configurations of the oocytes are arrested at the transition from the non-surrounded nucleolus to surrounded nucleolus-type and all oocytes die by P84 resulting in premature ovarian failure
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reproductive system
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• germinal vesicle oocytes from P21 mice are smaller
• following 12 hours of in vitro culture, about 90% of oocytes are arrested at the germinal vesicle stage instead of extruding the first polar body
• 90% of oocytes are non-surrounded nucleolus (NSN)-type instead of surrounded nucleolus (SN)-type at P21, suggesting a failure of the NSN to SN transition; these NSN-type oocytes show a lack of histone and DNA methylation and are unable to complete meiosis process
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• no oocytes are present by P84
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• total numbers of follicles in ovaries are increased at P11, but gradually decline from P14 to P84 and the numbers of follicles at P28, P42, and P84 are lower
• at P42, the numbers of follicles, including the pre-antral and antral follicles, are reduced due to follicle atresia and only a few follicles develop into antral follicles and form corporal lutea after ovulation
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• P11 ovaries contain more primordial follicles and fewer secondary follicles, indicating that most follicles are arrested at the primary follicle stage
• at P14, no antral follicles are seen in ovaries, although more pre-antral follicles are seen
• at P21, the number of primary and secondary follicles is increased, while few antral follicles are seen
• at P28, most follicles are still arrested at the pre-antral follicular stage, although a few follicles develop into antral follicles
• ovary shows poor response to treatment with pregnant mare serum gonadotropin (PMSG), indicating that follicles are mostly arrested in the pre-antral stage
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small ovary
(
J:278629
)
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• ovaries are smaller from P14 to P84, but are normal sized at P11
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• mice show retarded follicle development from pre-antral follicles to antral follicles, while the chromatin configurations of the oocytes are arrested at the transition from the non-surrounded nucleolus to surrounded nucleolus-type and all oocytes die by P84 resulting in premature ovarian failure
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endocrine/exocrine glands
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• total numbers of follicles in ovaries are increased at P11, but gradually decline from P14 to P84 and the numbers of follicles at P28, P42, and P84 are lower
• at P42, the numbers of follicles, including the pre-antral and antral follicles, are reduced due to follicle atresia and only a few follicles develop into antral follicles and form corporal lutea after ovulation
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• P11 ovaries contain more primordial follicles and fewer secondary follicles, indicating that most follicles are arrested at the primary follicle stage
• at P14, no antral follicles are seen in ovaries, although more pre-antral follicles are seen
• at P21, the number of primary and secondary follicles is increased, while few antral follicles are seen
• at P28, most follicles are still arrested at the pre-antral follicular stage, although a few follicles develop into antral follicles
• ovary shows poor response to treatment with pregnant mare serum gonadotropin (PMSG), indicating that follicles are mostly arrested in the pre-antral stage
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small ovary
(
J:278629
)
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• ovaries are smaller from P14 to P84, but are normal sized at P11
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• mice show retarded follicle development from pre-antral follicles to antral follicles, while the chromatin configurations of the oocytes are arrested at the transition from the non-surrounded nucleolus to surrounded nucleolus-type and all oocytes die by P84 resulting in premature ovarian failure
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cellular
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• germinal vesicle oocytes from P21 mice are smaller
• following 12 hours of in vitro culture, about 90% of oocytes are arrested at the germinal vesicle stage instead of extruding the first polar body
• 90% of oocytes are non-surrounded nucleolus (NSN)-type instead of surrounded nucleolus (SN)-type at P21, suggesting a failure of the NSN to SN transition; these NSN-type oocytes show a lack of histone and DNA methylation and are unable to complete meiosis process
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• no oocytes are present by P84
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