Phenotypes associated with this allele

• Allele Symbol: Fimp1^em1Osb
• Allele Name: endonuclease-mediated mutation 1, Research Institute for Microbial Diseases, Osaka University
• Allele ID: MGI:6460465
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fimp1^em1Osb/Fimp1^em1Osb	involves: C57BL/6NJcl * DBA/2NJcl	MGI:6460468

Genotype
MGI:6460468

hm1

• Allelic Composition: Fimp1^em1Osb/Fimp1^em1Osb
• Genetic Background: involves: C57BL/6NJcl * DBA/2NJcl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:287619 )

♂N • no gross abnormalities in testes morphology are detected

reduced male fertility ( J:287619 )

♂ • males are severely subfertile with an average of 0.5 +/- 0.8 pups per plug compared to 8.5 +/- 1.7 for wild-type controls

impaired fertilization ( J:287619 )

♂ • sperm penetrate the zona pellucida but rarely fertilize oocytes in vitro

♂ • sperm show an impaired ability to fuse with zona pellucida free oocytes