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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gt(ROSA)26Sortm1(CARD14*)Ribt
targeted mutation 1, Rudi Beyaert
MGI:6459917
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Gt(ROSA)26Sortm1(CARD14*)Ribt/Gt(ROSA)26Sor+
Tg(KRT5-cre)5132Jlj/0
involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl * DBA/2J MGI:6460069
cn2
Gt(ROSA)26Sortm1(CARD14*)Ribt/Gt(ROSA)26Sor+
Malt1tm1c(EUCOMM)Hmgu/Malt1tm1c(EUCOMM)Hmgu
Tg(KRT5-cre)5132Jlj/0
involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl * DBA/2J MGI:6460070
cn3
Gt(ROSA)26Sortm1(CARD14*)Ribt/Gt(ROSA)26Sor+
Tg(KRT14-cre/ERT)20Efu/0
involves: 129S6/SvEvTac * C57BL/6NCrl * CD-1 MGI:6460073
cn4
Gt(ROSA)26Sortm1(CARD14*)Ribt/Gt(ROSA)26Sor+
Malt1tm1c(EUCOMM)Hmgu/Malt1tm1c(EUCOMM)Hmgu
Tg(KRT14-cre/ERT)20Efu/0
involves: 129S6/SvEvTac * C57BL/6NCrl * CD-1 MGI:6460074


Genotype
MGI:6460069
cn1
Allelic
Composition
Gt(ROSA)26Sortm1(CARD14*)Ribt/Gt(ROSA)26Sor+
Tg(KRT5-cre)5132Jlj/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(CARD14*)Ribt mutation (0 available); any Gt(ROSA)26Sor mutation (944 available)
Tg(KRT5-cre)5132Jlj mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice delivered by Caesarian section do not survive beyond 24 hours after birth

integument
N
• mice exhibit normal epidermal skin barrier function




Genotype
MGI:6460070
cn2
Allelic
Composition
Gt(ROSA)26Sortm1(CARD14*)Ribt/Gt(ROSA)26Sor+
Malt1tm1c(EUCOMM)Hmgu/Malt1tm1c(EUCOMM)Hmgu
Tg(KRT5-cre)5132Jlj/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(CARD14*)Ribt mutation (0 available); any Gt(ROSA)26Sor mutation (944 available)
Malt1tm1c(EUCOMM)Hmgu mutation (0 available); any Malt1 mutation (33 available)
Tg(KRT5-cre)5132Jlj mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• mice exhibit normal postnatal survival




Genotype
MGI:6460073
cn3
Allelic
Composition
Gt(ROSA)26Sortm1(CARD14*)Ribt/Gt(ROSA)26Sor+
Tg(KRT14-cre/ERT)20Efu/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6NCrl * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(CARD14*)Ribt mutation (0 available); any Gt(ROSA)26Sor mutation (944 available)
Tg(KRT14-cre/ERT)20Efu mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• in tamoxifen-treated mice

integument
• in the basal layer of ear skin of tamoxifen-treated mice
• reminiscent of Munros abscesses in the stratum corneum in tamoxifen-treated mice
• in tamoxifen-treated mice
• in tamoxifen-treated mice
• in tamoxifen-treated mice
• in tamoxifen-treated mice
• from 6 weeks on, mice exhibit mild ear thickening unlike control mice
• tamoxifen-treated mice exhibit increased progressive ear swelling with ears becoming scaly and red unlike control mice

immune system
• in the ear of tamoxifen-treated mice
• in the ear of tamoxifen-treated mice
• reminiscent of Munros abscesses in the stratum corneum in tamoxifen-treated mice

growth/size/body
• in tamoxifen-treated mice

homeostasis/metabolism
• in tamoxifen-treated mice

cellular
• in the basal layer of ear skin of tamoxifen-treated mice

hematopoietic system
• in the ear of tamoxifen-treated mice
• in the ear of tamoxifen-treated mice




Genotype
MGI:6460074
cn4
Allelic
Composition
Gt(ROSA)26Sortm1(CARD14*)Ribt/Gt(ROSA)26Sor+
Malt1tm1c(EUCOMM)Hmgu/Malt1tm1c(EUCOMM)Hmgu
Tg(KRT14-cre/ERT)20Efu/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6NCrl * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(CARD14*)Ribt mutation (0 available); any Gt(ROSA)26Sor mutation (944 available)
Malt1tm1c(EUCOMM)Hmgu mutation (0 available); any Malt1 mutation (33 available)
Tg(KRT14-cre/ERT)20Efu mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• in tamoxifen-treated mice that is not as severe as in mice with wild-type Matl1
• in tamoxifen-treated mice that is not as severe as in mice with wild-type Matl1
• from 6 weeks on, mice exhibit mild ear thickening unlike control mice
• tamoxifen-treated mice exhibit increased ear swelling that is not as severe as in mice with wild-type Matl1

immune system
• in tamoxifen-treated mice that is not as severe as in mice with wild-type Matl1
• in tamoxifen-treated mice that is not as severe as in mice with wild-type Matl1
• in tamoxifen-treated mice that is not as severe as in mice with wild-type Matl1

growth/size/body
• in tamoxifen-treated that is not as severe as in mice with wild-type Matl1

hematopoietic system
• in tamoxifen-treated mice that is not as severe as in mice with wild-type Matl1
• in tamoxifen-treated mice that is not as severe as in mice with wild-type Matl1





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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory