Phenotypes associated with this allele

• Allele Symbol: Tg(Myh6-ACE2)1Rbre
• Allele Name: transgene insertion 1, Roger E Breitbart
• Allele ID: MGI:6459902
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Myh6-ACE2)1Rbre/0	involves: FVB/N	MGI:6459904

Genotype
MGI:6459904

tg1

• Allelic Composition: Tg(Myh6-ACE2)1Rbre/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased survivor rate ( J:128793 )

• approximate 40% long-term survival

premature death ( J:128793 )

• mice appear healthy but die prematurely, with 50% of mice dying by 23 weeks of age

cardiovascular system

abnormal myocardial fiber morphology ( J:128793 )

• hearts show rare focal myocyte vacuolization, myofibril splaying, and nuclear enlargement

cardiac interstitial fibrosis ( J:128793 )

• hearts show mild focal interstitial fibrosis

• however, hearts are grossly normal without hypertrophy or chamber enlargement, normal ventricular myocardium

decreased mean systemic arterial blood pressure ( J:128793 )

• lower mean arterial blood pressure at baseline and throughout the dobutamine dose range

liver/biliary system

focal hepatic necrosis ( J:128793 )

• focal apoptosis and necrosis in centrilobular areas of the liver

muscle

abnormal myocardial fiber morphology ( J:128793 )

• hearts show rare focal myocyte vacuolization, myofibril splaying, and nuclear enlargement

nervous system

abnormal hippocampus morphology ( J:128793 )

• focal apoptosis and necrosis in CA1/CA2 regions of the hippocampus

cellular

cardiac interstitial fibrosis ( J:128793 )

• hearts show mild focal interstitial fibrosis

• however, hearts are grossly normal without hypertrophy or chamber enlargement, normal ventricular myocardium

focal hepatic necrosis ( J:128793 )

• focal apoptosis and necrosis in centrilobular areas of the liver