Phenotypes associated with this allele

• Allele Symbol: Atxn2l^em1Aub
• Allele Name: endonuclease-mediated mutation 1, Georg Auburger
• Allele ID: MGI:6458736
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Atxn2l^em1Aub/Atxn2l^em1Aub	Not Specified	MGI:6458741

Genotype
MGI:6458741

hm1

• Allelic Composition: Atxn2l^em1Aub/Atxn2l^em1Aub
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:294770 )

• most mice die before E11, with female mice more affected than male mice

preweaning lethality, complete penetrance ( J:294770 )

• no mice are produced from breeding heterozygotes

nervous system

increased neuron apoptosis ( J:294770 )

• at E14

thin cerebral cortex ( J:294770 )

• at E14

growth/size/body

decreased fetal weight ( J:294770 )

• in surviving mice at E14 to E15, E15 to E16, and E20

fetal growth retardation ( J:294770 )

• at E16 in surviving mice

cellular

abnormal cell morphology ( J:294770 )

• increased number of giant multinucleated mouse embryonic fibroblasts

increased neuron apoptosis ( J:294770 )

• at E14