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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hmgcs2tm1Yil
targeted mutation 1, Omer Yilmaz
MGI:6457280
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Hmgcs2tm1Yil/Hmgcs2+ Not Specified MGI:8159405


Genotype
MGI:8159405
ht1
Allelic
Composition		 Hmgcs2tm1Yil/Hmgcs2+
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hmgcs2tm1Yil mutation (0 available); any Hmgcs2 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:280699 )
• at 3-6 months of age, heterozygotes show no differences in body weight, non-fasting blood glucose levels, serum ketone body (beta-hydroxybutyrate, betaOHB) levels, small intestine length, and crypt depth in proximal jejunum relative to wild-type controls
• Hmgcs2-expressing (Hmgcs2-lacZ+) crypt epithelial cells possess functional stem cell activity in organoid clonogenic assays




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory