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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Chd3tm1.1Cya
targeted mutation 1.1, Cyagen Biosciences
MGI:6456882
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Chd3tm1.1Cya/Chd3tm1.1Cya
Edil3Tg(Sox2-cre)1Amc/0 		involves: C57BL/6 * C57BL/6J * CBA MGI:6456931
cn2
 		Chd3tm1.1Cya/Chd3tm1.1Cya
Tg(Tek-cre)1Ywa/0 		involves: C57BL/6 * C57BL/6J * SJL MGI:6456932
cn3
 		Chd3tm1.1Cya/Chd3tm1.1Cya
Chd4tm1.1Kge/Chd4tm1.1Kge
Tg(Tek-cre)1Ywa/0 		involves: C57BL/6 * C57BL/6J * SJL MGI:6456933


Genotype
MGI:6456931
cn1
Allelic
Composition		 Chd3tm1.1Cya/Chd3tm1.1Cya
Edil3Tg(Sox2-cre)1Amc/0
Genetic
Background		 involves: C57BL/6 * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chd3tm1.1Cya mutation (0 available); any Chd3 mutation (101 available)
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, incomplete penetrance ( J:294633 )
• fewer than expected homozygous offspring are born

reproductive system




Genotype
MGI:6456932
cn2
Allelic
Composition		 Chd3tm1.1Cya/Chd3tm1.1Cya
Tg(Tek-cre)1Ywa/0
Genetic
Background		 involves: C57BL/6 * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chd3tm1.1Cya mutation (0 available); any Chd3 mutation (101 available)
Tg(Tek-cre)1Ywa mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:294633 )
N
• normal embryonic vasculature
abnormal blood vessel morphology ( J:294633 )
• no obvious anomalies

mortality/aging
mortality/aging ( J:294633 )
N
• viable; mice born at expected Mendelian ratio




Genotype
MGI:6456933
cn3
Allelic
Composition		 Chd3tm1.1Cya/Chd3tm1.1Cya
Chd4tm1.1Kge/Chd4tm1.1Kge
Tg(Tek-cre)1Ywa/0
Genetic
Background		 involves: C57BL/6 * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chd3tm1.1Cya mutation (0 available); any Chd3 mutation (101 available)
Chd4tm1.1Kge mutation (0 available); any Chd4 mutation (58 available)
Tg(Tek-cre)1Ywa mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal blood vessel morphology ( J:294633 )
• vascular rupture in E11.5 embryos
• normal vasculature in E10.5 embryos
hemorrhage ( J:294633 )
• in E11.5 embryos

mortality/aging
embryonic lethality, complete penetrance ( J:294633 )
• most embryos die between age E10.5-11.5




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory