All Phenotypes Mir149<em1Ydw> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mir149^em1Ydw
endonuclease-mediated mutation 1, Yan-Dong Wang
MGI:6455680

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mir149^em1Ydw/Mir149^em1Ydw	C57BL/6J-Mir149^em1Ydw	MGI:6455684

Allelic Composition	Mir149^em1Ydw/Mir149^em1Ydw
Genetic Background	C57BL/6J-Mir149^em1Ydw

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir149^em1Ydw mutation (0 available); any Mir149 mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

liver/biliary system

increased hepatocyte apoptosis ( J:294318 )

• in LPS-treated mice

increased hepatocyte proliferation ( J:294318 )

• prior to and after LPS-treatment

immune system

increased susceptibility to endotoxin shock ( J:294318 )

• mice treated with LPS exhibit increased inflammation and injury (as measured by increased AST levels, hepatocyte apoptosis, and hepatocyte proliferation) compared with wild-type mice

homeostasis/metabolism

increased circulating aspartate transaminase level ( J:294318 )

• in LPS-treated mice

cellular

increased hepatocyte apoptosis ( J:294318 )

• in LPS-treated mice

increased hepatocyte proliferation ( J:294318 )

• prior to and after LPS-treatment

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