Phenotypes associated with this allele

• Allele Symbol: Polr3gl^tm1Rgr
• Allele Name: targeted mutation 1, Robert G Roeder
• Allele ID: MGI:6455458
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Polr3gl^tm1Rgr/Polr3gl^tm1Rgr	involves: C57BL/6	MGI:6455472
cx2	Polr3g^tm1Rgr/Polr3g^tm1Rgr Polr3gl^tm1Rgr/Polr3gl^+	involves: C57BL/6	MGI:6455471

Genotype
MGI:6455472

hm1

• Allelic Composition: Polr3gl^tm1Rgr/Polr3gl^tm1Rgr
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:291033 )

• mice have an average life span of 10 days and all mice die after P16

behavior/neurological

ataxia ( J:291033 )

impaired balance ( J:291033 )

• poor body balance

growth/size/body

decreased body weight ( J:291033 )

• in postnatal mice

postnatal growth retardation ( J:291033 )

• severe

nervous system

cerebellum hypoplasia ( J:291033 )

• at P20 to P22 relative to body weight

Genotype
MGI:6455471

cx2

• Allelic Composition: Polr3g^tm1Rgr/Polr3g^tm1Rgr; Polr3gl^tm1Rgr/Polr3gl⁺
• Genetic Background: involves: C57BL/6

mortality/aging

embryonic lethality between implantation and placentation, complete penetrance ( J:291033 )

• mice died between E3.5 and E6.5

embryo

embryonic growth arrest ( J:291033 )

• in most mice