Phenotypes associated with this allele

• Allele Symbol: Ctrb1^em1Toth
• Allele Name: endonuclease-mediated mutation 1, Miklos Toth
• Allele ID: MGI:6455002
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ctrb1^em1Toth/Ctrb1^em1Toth	C57BL/6N-Ctrb1^em1Toth	MGI:6455007

Genotype
MGI:6455007

hm1

• Allelic Composition: Ctrb1^em1Toth/Ctrb1^em1Toth
• Genetic Background: C57BL/6N-Ctrb1^em1Toth

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

enlarged pancreas ( J:294171 )

• in cerulein-treated mice

increased pancreas weight ( J:294171 )

• in cerulein-treated mice

abnormal pancreas physiology ( J:294035 )

• cerulein-treated mice exhibit reduced intrapancreatic chymotrypsin activation compared with control mice

increased susceptibility to induced pancreatitis ( J:294171 , J:294035 )

• mice treated with cerulein exhibit increased intrapancreatic trypsin activity, increased pancreas size and weight, edema, and more severe pancreatitis than in control mice (J:294171)

• cerulein-treated mice exhibit increased (J:294035)

homeostasis/metabolism

edema ( J:294171 )

• in cerulein-treated mice

immune system

increased susceptibility to induced pancreatitis ( J:294171 , J:294035 )

• mice treated with cerulein exhibit increased intrapancreatic trypsin activity, increased pancreas size and weight, edema, and more severe pancreatitis than in control mice (J:294171)

• cerulein-treated mice exhibit increased (J:294035)

growth/size/body

enlarged pancreas ( J:294171 )

• in cerulein-treated mice

increased pancreas weight ( J:294171 )

• in cerulein-treated mice