Phenotypes associated with this allele

• Allele Symbol: Gprc5a^em1Jaap
• Allele Name: endonuclease-mediated mutation 1, Jaakko Patrakka
• Allele ID: MGI:6452643
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gprc5a^em1Jaap/Gprc5a^em1Jaap	FVB-Gprc5a^em1Jaap	MGI:6452803

Genotype
MGI:6452803

hm1

• Allelic Composition: Gprc5a^em1Jaap/Gprc5a^em1Jaap
• Genetic Background: FVB-Gprc5a^em1Jaap

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

growth/size/body region phenotype ( J:293292 )

N • normal development and no macroscopic or histological abnormalities in major organs

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:293292 )

N • no albuminuria at age 2 or 12 months

albuminuria ( J:293292 )

• from 5 weeks after induction of diabetes with streptozotocin (STZ)

• no albuminuria at age 2 or 12 months

mortality/aging

mortality/aging ( J:293292 )

N • mice born at normal Mendelian ratio

renal/urinary system

renal/urinary system phenotype ( J:293292 )

N • normal renal histology at birth and at age 2 months

N • normal tubulointerstitial morphology at age 12 months

albuminuria ( J:293292 )

• from 5 weeks after induction of diabetes with streptozotocin (STZ)

• no albuminuria at age 2 or 12 months

podocyte foot process effacement ( J:293292 )

• focal segmental foot process effacement 24 weeks after induction of diabetes with streptozotocin (STZ)

increased renal glomerulus basement membrane thickness ( J:293292 )

• at age 12 months

expanded mesangial matrix ( J:293292 )

• at age 12 months

• more prominent 24 weeks after induction of diabetes with streptozotocin (STZ) then in WT

• normal renal histology at birth and at age 2 months

glomerulosclerosis ( J:293292 )

• focal segmental glomerulosclerosis (FSGS) as well as complete sclerosis 24 weeks after induction of diabetes with streptozotocin (STZ)