All Phenotypes Myocd<em1Blk> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Myocd^em1Blk
endonuclease-mediated mutation 1, Brian L Black
MGI:6450718

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Myocd^em1Blk/Myocd^tm1.1Msp	involves: 129	MGI:6450809

Allelic Composition	Myocd^em1Blk/Myocd^tm1.1Msp
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myocd^em1Blk mutation (0 available); any Myocd mutation (55 available)
Myocd^tm1.1Msp mutation (0 available); any Myocd mutation (55 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:283803 )

• unlike mice homozygous for Myocd^tm1.1Msp, mice survive to birth but die by 1 week of age

renal/urinary system

abnormal urinary bladder morphology ( J:283803 )

• thin bladder wall

abnormal urinary bladder detrusor smooth muscle morphology ( J:283803 )

• little or no smooth muscle in the bladder wall

distended urinary bladder ( J:283803 )

• grossly dilated bladder at P1

cardiovascular system

cardiovascular system phenotype ( J:283803 )

N	• no gross cardiac defects

muscle

abnormal urinary bladder detrusor smooth muscle morphology ( J:283803 )

• little or no smooth muscle in the bladder wall

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
congenital megabladder		DOID:0112014	OMIM:618719	J:283803

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/30/2025 MGI 6.24