Phenotypes associated with this allele

• Allele Symbol: Grxcr2^tm1Dck
• Allele Name: targeted mutation 1, David Kohrman
• Allele ID: MGI:6450519
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Grxcr2^tm1Dck/Grxcr2^tm1Dck	B6.Cg-Grxcr2^tm1Dck	MGI:6470737

Genotype
MGI:6470737

hm1

• Allelic Composition: Grxcr2^tm1Dck/Grxcr2^tm1Dck
• Genetic Background: B6.Cg-Grxcr2^tm1Dck

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hearing/vestibular/ear

abnormal outer hair cell stereociliary bundle morphology ( J:265041 )

• organ of Corti shows altered stereocilia bundles in a small number of outer hair cells at 2 months of age and severe bundle defects in nearly all outer hair cells at 7 months of age

• bundle defects include flattened, split and misoriented bundles

abnormal orientation of outer hair cell stereociliary bundles ( J:265041 )

• bundle defects include misoriented bundles

increased or absent threshold for auditory brainstem response ( J:265041 )

• 2-month old mice exhibit elevated auditory brainstem response (ABR) thresholds to 4 kHz tones but normal thresholds to 12 and 24 kHz tones

• 5-month old mice exhibit increased ABR thresholds to 4 and 12 kHz tones

impaired hearing ( J:265041 )

• mice exhibit progressive hearing loss by 5 months of age

nervous system

abnormal outer hair cell stereociliary bundle morphology ( J:265041 )

• organ of Corti shows altered stereocilia bundles in a small number of outer hair cells at 2 months of age and severe bundle defects in nearly all outer hair cells at 7 months of age

• bundle defects include flattened, split and misoriented bundles

abnormal orientation of outer hair cell stereociliary bundles ( J:265041 )

• bundle defects include misoriented bundles