Phenotypes associated with this allele

• Allele Symbol: Top2b^em1(IMPC)Mbp
• Allele Name: endonuclease-mediated mutation 1, Mouse Biology Program, UC Davis
• Allele ID: MGI:6449041
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Top2b^em1(IMPC)Mbp/Top2b^em1(IMPC)Mbp	C57BL/6NCrl-Top2b^em1(IMPC)Mbp/Mmucd	MGI:7415129
ht2	Top2b^em1(IMPC)Mbp/Top2b^+	C57BL/6NCrl-Top2b^em1(IMPC)Mbp/Mmucd	MGI:7415128

Genotype
MGI:7415129

hm1

• Allelic Composition: Top2b^em1(IMPC)Mbp/Top2b^em1(IMPC)Mbp
• Genetic Background: C57BL/6NCrl-Top2b^em1(IMPC)Mbp/Mmucd

Data Sources

IMPC Data for Top2b

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

abnormal craniofacial morphology ( J:211773 )

IMPC - UCD

cleft palate ( J:211773 )

IMPC - UCD

abnormal head shape ( J:211773 )

♀

IMPC - UCD

digestive/alimentary system

cleft palate ( J:211773 )

IMPC - UCD

embryo

embryonic growth retardation ( J:211773 )

IMPC - UCD

abnormal placenta morphology ( J:211773 )

♀

IMPC - UCD

growth/size/body

cleft palate ( J:211773 )

IMPC - UCD

abnormal head shape ( J:211773 )

♀

IMPC - UCD

embryonic growth retardation ( J:211773 )

IMPC - UCD

homeostasis/metabolism

edema ( J:211773 )

IMPC - UCD

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - UCD

Genotype
MGI:7415128

ht2

• Allelic Composition: Top2b^em1(IMPC)Mbp/Top2b⁺
• Genetic Background: C57BL/6NCrl-Top2b^em1(IMPC)Mbp/Mmucd

Data Sources

IMPC Data for Top2b

hematopoietic system

abnormal spleen morphology ( J:211773 )

IMPC - UCD

small spleen ( J:211773 )

IMPC - UCD

immune system

abnormal spleen morphology ( J:211773 )

IMPC - UCD

small spleen ( J:211773 )

IMPC - UCD

vision/eye

abnormal eye morphology ( J:211773 )

♂

IMPC - UCD

persistence of hyaloid vascular system ( J:211773 )

IMPC - UCD