Phenotypes associated with this allele

• Allele Symbol: Dnm1l^em1Hise
• Allele Name: endonuclease-mediated mutation 1, Hiromi Sesaki
• Allele ID: MGI:6448439
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dnm1l^em1Hise/Dnm1l^em1Hise	involves: C57BL/6J * SJL/J	MGI:6448491
cx2	Dnm1l^em1Hise/Dnm1l^em1Hise Tg(Thy1-EGFP)MJrs/0	involves: C57BL/6J * CBA * SJL/J	MGI:6448493

Genotype
MGI:6448491

hm1

• Allelic Composition: Dnm1l^em1Hise/Dnm1l^em1Hise
• Genetic Background: involves: C57BL/6J * SJL/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal dendritic spine morphology ( J:291773 )

• increased number of primary dendrites with dendritic spines in cultured hippocampal neurons from E18.5 embryos

• normal number axons of without spines in cultured hippocampal neurons from E18.5 embryos

• normal dendritic spine density and number of dendritic branches in cultured hippocampal neurons from E18.5 embryos

abnormal synapse morphology ( J:291773 )

• increased number of clathrin-coated pits (CCPs) in postsynaptic terminals of cultured hippocampal neurons from E18.5 embryos

• normal number of clathrin-coated pits (CCPs) in presynaptic terminals of cultured hippocampal neurons from E18.5 embryos

• higher frequency of shallow and U-shaped CCPs in postsynaptic terminals of cultured hippocampal neurons from E18.5 embryos

• normal frequency of omega-shaped CCPs in postsynaptic terminals of cultured hippocampal neurons from E18.5 embryos

enhanced sensorimotor gating ( J:291773 )

• significantly increased PPI of acoustic startle

increased prepulse inhibition ( J:291773 )

• significantly increased PPI of acoustic startle

behavior/neurological

behavior/neurological phenotype ( J:291773 )

N • normal general locomotor behavior in open field test and normal acoustic startle reflex

N • normal spatial working and recognition memory tasks in Y-maze tests, normal motor coordination in rotarod test and normal anxiety level in elevated plus maze test

cellular

cellular phenotype ( J:291773 )

N • normal mitochondrial morphology in in proximal and distal regions of hippocampal dendrites

Genotype
MGI:6448493

cx2

• Allelic Composition: Dnm1l^em1Hise/Dnm1l^em1Hise; Tg(Thy1-EGFP)MJrs/0
• Genetic Background: involves: C57BL/6J * CBA * SJL/J

nervous system

abnormal neurite morphology ( J:291773 )

• increased number of neurites in CA1 and CA2 layers of dorsal hippocampus

abnormal dendritic spine morphology ( J:291773 )

• increased number of primary dendrites with dendritic spines in CA1 and CA2 layers of dorsal hippocampus

cellular

cellular phenotype ( J:291773 )

N • normal mitochondrial morphology in in proximal and distal regions of hippocampal dendrites