Phenotypes associated with this allele

• Allele Symbol: Mir505^em1Xhj
• Allele Name: endonuclease-mediated mutation 1, Junhua Xiao
• Allele ID: MGI:6444855
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mir505^em1Xhj/Mir505^em1Xhj	C57BL/6J-Mir505^em1Xhj	MGI:6446187
ht2	Mir505^em1Xhj/Mir505^+	C57BL/6J-Mir505^em1Xhj	MGI:6446192

Genotype
MGI:6446187

hm1

• Allelic Composition: Mir505^em1Xhj/Mir505^em1Xhj
• Genetic Background: C57BL/6J-Mir505^em1Xhj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

increased corpora lutea number ( J:289998 )

♀

increased ovary weight ( J:289998 )

♀

increased uterus weight ( J:289998 )

♀

early sexual maturation ( J:289998 )

♀ • 3.57 days earlier vaginal opening

early vaginal opening ( J:289998 )

♀ • 3.57 days earlier vaginal opening

dystocia ( J:289998 )

♀ • with more dead offspring from female mice

increased litter size ( J:289998 )

♀ • from female mice

growth/size/body

increased ovary weight ( J:289998 )

♀

decreased body weight ( J:289998 )

♀ • at age of vaginal opening

increased body weight ( J:289998 )

♀ • until day 40 in female mice

♀ • however, male mice exhibit normal weight

increased growth rate ( J:289998 )

♀ • in female mice

homeostasis/metabolism

increased circulating follicle stimulating hormone level ( J:289998 )

♀

increased circulating luteinizing hormone level ( J:289998 )

♀

endocrine/exocrine glands

increased corpora lutea number ( J:289998 )

♀

increased ovary weight ( J:289998 )

♀

Genotype
MGI:6446192

ht2

• Allelic Composition: Mir505^em1Xhj/Mir505⁺
• Genetic Background: C57BL/6J-Mir505^em1Xhj

reproductive system

early sexual maturation ( J:289998 )

♀ • 3.87 days earlier vaginal opening

early vaginal opening ( J:289998 )

♀ • 3.87 days earlier vaginal opening

growth/size/body

decreased body weight ( J:289998 )

♀ • at age of vaginal opening