About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fam151aem1Jkn
endonuclease-mediated mutation 1, Ian J Jackson
MGI:6442001
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Fam151aem1Jkn/Fam151aem1Jkn involves: C57BL/6J MGI:6442005
cx2
 		Fam151aem1Jkn/Fam151aem1Jkn
Fam151btm1b(EUCOMM)Hmgu/Fam151btm1b(EUCOMM)Hmgu 		involves: C57BL/6J * C57BL/6N * C57BL/6NTac MGI:6442006


Genotype
MGI:6442005
hm1
Allelic
Composition		 Fam151aem1Jkn/Fam151aem1Jkn
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fam151aem1Jkn mutation (0 available); any Fam151a mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:284934 )
N
• normal heart weight

vision/eye
vision/eye phenotype ( J:284934 )
N
• ERG analysis found no decrease in retinal response to a light stimulus: normal a-waves and b-waves at age one year
• normal gross retinal morphology, no loss of photoreceptor cells nor increased GFAP staining




Genotype
MGI:6442006
cx2
Allelic
Composition		 Fam151aem1Jkn/Fam151aem1Jkn
Fam151btm1b(EUCOMM)Hmgu/Fam151btm1b(EUCOMM)Hmgu
Genetic
Background		 involves: C57BL/6J * C57BL/6N * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fam151aem1Jkn mutation (0 available); any Fam151a mutation (35 available)
Fam151btm1b(EUCOMM)Hmgu mutation (0 available); any Fam151b mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
decreased photoreceptor outer segment number ( J:284934 )
• severely reduced layer thickness and number of photoreceptor cell nuclei at age P21
short photoreceptor outer segment ( J:284934 )
• severely reduced layer thickness and number of photoreceptor cell nuclei at age P21
photoreceptor outer segment degeneration ( J:284934 )
• reduced layer thickness at age P21

pigmentation
abnormal retina pigmentation ( J:284934 )
• patchy pigmentation at age P21

vision/eye
decreased photoreceptor outer segment number ( J:284934 )
• severely reduced layer thickness and number of photoreceptor cell nuclei at age P21
short photoreceptor outer segment ( J:284934 )
• severely reduced layer thickness and number of photoreceptor cell nuclei at age P21
photoreceptor outer segment degeneration ( J:284934 )
• reduced layer thickness at age P21
abnormal retina pigmentation ( J:284934 )
• patchy pigmentation at age P21




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory