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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tuba4am1Frla
mutation 1, Francois Lanza
MGI:6441799
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Tuba4am1Frla/Tuba4am1Frla BALB/c-Tuba4am1Frla MGI:6441801


Genotype
MGI:6441801
hm1
Allelic
Composition
Tuba4am1Frla/Tuba4am1Frla
Genetic
Background
BALB/c-Tuba4am1Frla
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tuba4am1Frla mutation (0 available); any Tuba4a mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• normal distribution of stage I-III MKs in bone marrow
• more compact demarcation membrane in 30% of stage III bone marrow MKs
• inability of stage III bone marrow MKs to extend well-developed proplatelets

hematopoietic system
• normal distribution of stage I-III MKs in bone marrow
• more compact demarcation membrane in 30% of stage III bone marrow MKs
• inability of stage III bone marrow MKs to extend well-developed proplatelets
• reduction in number of MT coils in marginal band
• 21% reduction in platelet count
• 143% of wild-type MPV





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory