Phenotypes associated with this allele

• Allele Symbol: Sipa1l2^tm1Mrkr
• Allele Name: targeted mutation 1, Michael R Kreutz
• Allele ID: MGI:6441768
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sipa1l2^tm1Mrkr/Sipa1l2^tm1Mrkr	B6.129S-Sipa1l2^tm1Mrkr	MGI:6441794

Genotype
MGI:6441794

hm1

• Allelic Composition: Sipa1l2^tm1Mrkr/Sipa1l2^tm1Mrkr
• Genetic Background: B6.129S-Sipa1l2^tm1Mrkr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:286683 )

N • normal object location recognition and novel object recognition behavior

abnormal long-term spatial reference memory ( J:286683 )

• strong impairment in spatial pattern separation in the similar location recognition (SLR) test

• normal behavior in the dissimilar location recognition (dSLR) test

nervous system

nervous system phenotype ( J:286683 )

N • normal gross anatomy of cerebellum, dentate gyrus (DG), adult-born granule cells, normal measures of general DG excitability and postsynaptic function and normal motor learning and coordination

N • normal ultrastructure of presynaptic boutons and vesicle content

reduced long-term potentiation ( J:286683 )

• in mossy fiber (MF) boutons of DG granule cells