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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Card14em3Tshu
endonuclease-mediated mutation 3, Tsinghua University
MGI:6441137
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Card14em3Tshu/Card14+ involves: C57BL/6 MGI:6441187
cx2
 		Card14em3Tshu/Card14+
Il17atm1Cdon/Il17atm1Cdon 		involves: C57BL/6 MGI:6441426


Genotype
MGI:6441187
ht1
Allelic
Composition		 Card14em3Tshu/Card14+
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Card14em3Tshu mutation (0 available); any Card14 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
skin inflammation ( J:289239 )
• redness and swelling of ears up to approximately 12 weeks of age
thick epidermis ( J:289239 )
• epidermal thickening in the tails at 18 and 36 days of age
psoriasis ( J:289239 )
• mice develop a weak psoriasis-like phenotype

immune system
skin inflammation ( J:289239 )
• redness and swelling of ears up to approximately 12 weeks of age




Genotype
MGI:6441426
cx2
Allelic
Composition		 Card14em3Tshu/Card14+
Il17atm1Cdon/Il17atm1Cdon
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Card14em3Tshu mutation (0 available); any Card14 mutation (38 available)
Il17atm1Cdon mutation (0 available); any Il17a mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased inflammatory response ( J:289239 )
• the increase in ear thickness indicative of skin inflammation that is seen in heterozygous Card14em3Tshu mice is partially reduced




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory