Phenotypes associated with this allele

• Allele Symbol: Dmd^em4Eno
• Allele Name: endonuclease-mediated mutation 4, Eric N Olson
• Allele ID: MGI:6438148
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dmd^em4Eno/Dmd^em4Eno	C57BL/6-Dmd^em4Eno	MGI:6438177
ot2	Dmd^em4Eno/Y	C57BL/6-Dmd^em4Eno	MGI:6438180

Genotype
MGI:6438177

hm1

• Allelic Composition: Dmd^em4Eno/Dmd^em4Eno
• Genetic Background: C57BL/6-Dmd^em4Eno

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

myositis ( J:285447 )

♀ • 4-week old mice exhibit inflammatory infiltration in muscles

centrally nucleated skeletal muscle fibers ( J:285447 )

♀ • muscles show regenerative fibers with centralized nuclei

skeletal muscle fiber degeneration ( J:285447 )

♀

skeletal muscle fibrosis ( J:285447 )

♀ • in 4-week old mice

dystrophic muscle ( J:285447 )

♀ • mice exhibit severe muscular dystrophy phenotype as indicated by fibrosis, inflammatory infiltration, and regenerative fibers with centralized nuclei at 4 weeks of age

muscle weakness ( J:285447 )

♀ • mice exhibit an approximate 50% decrease in the specific and absolute tetanic force in the extensor digitorum longus muscle at 4 weeks of age

behavior/neurological

decreased grip strength ( J:285447 )

♀ • grip strength analysis indicates a decrease in muscle strength in 8 week old mice

homeostasis/metabolism

increased circulating creatine kinase level ( J:285447 )

♀ • serum creatine kinase levels are elevated 22-fold

immune system

myositis ( J:285447 )

♀ • 4-week old mice exhibit inflammatory infiltration in muscles

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Duchenne muscular dystrophy		DOID:11723	OMIM:310200	J:285447

Genotype
MGI:6438180

ot2

• Allelic Composition: Dmd^em4Eno/Y
• Genetic Background: C57BL/6-Dmd^em4Eno

muscle

myositis ( J:285447 )

♂ • 4-week old mice exhibit inflammatory infiltration in muscles

centrally nucleated skeletal muscle fibers ( J:285447 )

♂ • muscles show regenerative fibers with centralized nuclei

skeletal muscle fiber degeneration ( J:285447 )

♂

skeletal muscle fibrosis ( J:285447 )

♂ • in 4-week old mice

dystrophic muscle ( J:285447 )

♂ • mice exhibit severe muscular dystrophy phenotype as indicated by fibrosis, inflammatory infiltration, and regenerative fibers with centralized nuclei at 4 weeks of age

muscle weakness ( J:285447 )

♂ • mice exhibit an approximate 50% decrease in the specific and absolute tetanic force in the extensor digitorum longus muscle at 4 weeks of age

behavior/neurological

decreased grip strength ( J:285447 )

♂ • grip strength analysis indicates a decrease in muscle strength in 8 week old mice

homeostasis/metabolism

increased circulating creatine kinase level ( J:285447 )

♂ • serum creatine kinase levels are elevated 22-fold

immune system

myositis ( J:285447 )

♂ • 4-week old mice exhibit inflammatory infiltration in muscles

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Duchenne muscular dystrophy		DOID:11723	OMIM:310200	J:285447