Phenotypes associated with this allele

• Allele Symbol: Llcfc1^em2Osb
• Allele Name: endonuclease-mediated mutation 2, Research Institute for Microbial Diseases, Osaka University
• Allele ID: MGI:6437831
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Llcfc1^em2Osb/Llcfc1^em2Osb	involves: 129S2/SvPas * C57BL/6 * C57BL/6NSlc * DBA/2	MGI:6437833

Genotype
MGI:6437833

hm1

• Allelic Composition: Llcfc1^em2Osb/Llcfc1^em2Osb
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6NSlc * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

male infertility ( J:289149 )

♂ • in in vitro fertilization with cumulus-intact oocytes, spermatozoa are able to penetrate zona pellucida but accumulate in the perivitelline space and are unable to fertilize oocytes

♂ • spermatozoa are unable to fertilize zona pellucida-free oocytes

♂ • however, testis morphology and weight are normal, no defects in spermatogenesis are seen, and spermatozoa morphology is normal

failure of sperm-egg fusion ( J:289149 )

• spermatozoa are able to bind to the oocyte membrane but not fuse with it