All Phenotypes Rbm20<em1Hide> MGI Mouse

mortality/aging

premature death ( J:297234 )

• sudden unexpected death is seen in 30% of mice during a 36-week follow-up

cardiovascular system

enlarged heart ( J:297234 )

• hearts show enlarged cardiac chambers at 4 weeks of age which is exacerbated at 12 weeks of age

thin ventricular wall ( J:297234 )

• hearts show thinning of the ventricular wall at 4 weeks of age which is exacerbated at 12 weeks of age

cardiac fibrosis ( J:297234 )

• cardiac fibrosis is seen at 4 weeks of age and fibrotic left ventricle changes are exacerbated at 12 weeks of age

dilated cardiomyopathy ( J:297234 )

decreased cardiac muscle contractility ( J:297234 )

• ultrasound echocardiography shows a far lower fractional shortening at 12-16 weeks of age than in wild-type mice

abnormal heart echocardiography feature ( J:297234 )

• ultrasound echocardiography shows a far lower fractional shortening, larger left ventricular end-diastolic diameter, and thinner end-diastolic left ventricular posterior wall thickness at 12-16 weeks of age

• mice show lower percent fractional shortening, larger left ventricle end-diastolic diameter, and lower end-diastolic left ventricular poster wall thickness at 4 weeks of age, when atrial fibrillation is not observed

ventricular tachycardia ( J:297234 )

• 2 of 3 mice show spontaneous, sustained, and self-terminating ventricular tachycardia and ventricular fibrillation

• during ventricular tachycardia episode, mice suffer syncope

atrial fibrillation ( J:297234 )

• mice start developing atrial fibrillation at approximately 4 weeks and atrial fibrillation is present in all mice at 10 weeks of age

ventricular fibrillation ( J:297234 )

• 2 of 3 mice show spontaneous, sustained, and self-terminating ventricular tachycardia and ventricular fibrillation

prolonged PR interval ( J:297234 )

• prolonged PR interval in 4-week old mice

prolonged P wave ( J:297234 )

• prolonged P wave duration in 4-week old mice

prolonged QRS complex duration ( J:297234 )

• prolonged QRS duration in 4-week old mice

prolonged QT interval ( J:297234 )

• prolonged heart rate-corrected QT interval in 4-week old mice

abnormal R wave ( J:297234 )

• smaller R amplitude in 4-week old mice

syncope ( J:297234 )