About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gpr35em1Niess
endonuclease-mediated mutation 1, Jan Hendrik Niess
MGI:6436880
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gpr35em1Niess/Gpr35em1Niess C57BL/6N-Gpr35em1Niess MGI:6502845


Genotype
MGI:6502845
hm1
Allelic
Composition		 Gpr35em1Niess/Gpr35em1Niess
Genetic
Background		 C57BL/6N-Gpr35em1Niess
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpr35em1Niess mutation (0 available); any Gpr35 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
decreased colon length ( J:300275 )
• in DSS-treated mice
increased susceptibility to induced colitis ( J:300275 )
• DSS-treated mice exhibit elevated body weight loss, increased disease activity scores, shorter colons, and higher histological colitis scores compared with wild-type mice

growth/size/body
increased susceptibility to weight loss ( J:300275 )
• in DSS-treated mice

immune system
immune system phenotype ( J:300275 )
N
• mice exhibit normal colonic myeloid compartment
increased susceptibility to induced colitis ( J:300275 )
• DSS-treated mice exhibit elevated body weight loss, increased disease activity scores, shorter colons, and higher histological colitis scores compared with wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory