Phenotypes associated with this allele

• Allele Symbol: Kprp^tm1Msug
• Allele Name: targeted mutation 1, Makoto Sugaya
• Allele ID: MGI:6429935
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kprp^tm1Msug/Kprp^tm1Msug	involves: C57BL/6	MGI:6429937
ht2	Kprp^tm1Msug/Kprp^+	involves: C57BL/6	MGI:6429936

Genotype
MGI:6429937

hm1

• Allelic Composition: Kprp^tm1Msug/Kprp^tm1Msug
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

abnormal skin morphology ( J:286659 )

• homozygotes show similar phenotypes to heterozygous mice

Genotype
MGI:6429936

ht2

• Allelic Composition: Kprp^tm1Msug/Kprp⁺
• Genetic Background: involves: C57BL/6

integument

impaired skin barrier function ( J:286659 )

• transepidermal water loss is increased, indicating impaired skin barrier

increased susceptibility to chemically induced skin inflammation ( J:286659 )

• mice show enhanced percutaneous immune responses to irritants and allergens, showing enhanced ear-swelling responses after topical application of croton oil and increased ear thickness after the application of ozazolone

abnormal skin morphology ( J:286659 )

• cristae cutis and sulci cutis abnormality

abnormal epidermal layer morphology ( J:286659 )

• density of corneodesmosomes in the epidermis tends to be lower at the border between the stratum granulosum and stratum corneum and the expression layers of corneodesmosin is thinner

• abnormal desmosome structure

abnormal epidermis stratum corneum morphology ( J:286659 )

• epidermis shows detachment of the stratum corneum from the lower layer

decreased keratohyalin granule number ( J:286659 )

• fewer keratohyalin granules in the epidermis

thin epidermis stratum granulosum ( J:286659 )

immune system

increased IgE level ( J:286659 )

• mice exhibit higher level of OVA-specific IgE following repeated epicutaneous immunization with OVA indicating enhanced percutaneous immune responses

increased susceptibility to chemically induced skin inflammation ( J:286659 )

• mice show enhanced percutaneous immune responses to irritants and allergens, showing enhanced ear-swelling responses after topical application of croton oil and increased ear thickness after the application of ozazolone

homeostasis/metabolism

impaired skin barrier function ( J:286659 )

• transepidermal water loss is increased, indicating impaired skin barrier

hematopoietic system

increased IgE level ( J:286659 )

• mice exhibit higher level of OVA-specific IgE following repeated epicutaneous immunization with OVA indicating enhanced percutaneous immune responses