Phenotypes associated with this allele

• Allele Symbol: Lmna^tm1.1Bliu
• Allele Name: targeted mutation 1.1, Baohua Liu
• Allele ID: MGI:6423596
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lmna^tm1.1Bliu/Lmna^tm1.1Bliu	involves: C57BL/6 * FVB/N	MGI:6423598
ht2	Lmna^tm1.1Bliu/Lmna^+	involves: C57BL/6 * FVB/N	MGI:6423601

Genotype
MGI:6423598

hm1

• Allelic Composition: Lmna^tm1.1Bliu/Lmna^tm1.1Bliu
• Genetic Background: involves: C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:287256 )

• shorter median life span of 21 weeks

growth/size/body

weight loss ( J:287256 )

• body weight loss from 8 weeks of age

postnatal growth retardation ( J:287256 )

cardiovascular system

increased aorta wall thickness ( J:287256 )

• intima-media thickening

abnormal vasodilation ( J:287256 )

• acetylcholine-induced thoracic aorta relaxation is compromised

muscle

abnormal vasodilation ( J:287256 )

• acetylcholine-induced thoracic aorta relaxation is compromised

Genotype
MGI:6423601

ht2

• Allelic Composition: Lmna^tm1.1Bliu/Lmna⁺
• Genetic Background: involves: C57BL/6 * FVB/N

mortality/aging

premature death ( J:287256 )

• shortened life span

growth/size/body

postnatal growth retardation ( J:287256 )

cardiovascular system

abnormal vasodilation ( J:287256 )

• acetylcholine-induced thoracic aorta relaxation is compromised

muscle

abnormal vasodilation ( J:287256 )

• acetylcholine-induced thoracic aorta relaxation is compromised